Protein AF1q Antibodies

AND MLLT11 ELISA kits, Protein AF1q Proteins

Many biological assays use antibodies to detect Protein AF1q, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein AF1q in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein AF1q antibodies...

We validate the specificity of these antibodies to Protein AF1q by testing them on tissues known to express MLLT11 positively and negatively. Browse below to find the MLLT11 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MLLT11 Infographic by Boster Bio

All MLLT11 Products

Product

Figures

Specificity

Applications

Price

Human MLLT11 Recombinant Protein

SDS-PAGE, Denatured

$265
Cat # PROTQ13015
Starting from 20ug

MLLT11 Overview

Facts about Protein AF1q.

MLLT11 3D structure. Source: alphafold

Protein AF1q (MLLT11)

Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312).

Gene Information

Human
Gene Name:	MLLT11
Uniprot:	Q13015
Entrez:	10962

Family

Belongs to:

MLLT11 family

Alternative Names

AF1QRP11-316M1.10; ALL1 fused gene from chromosome 1q; ALL1-fused gene from chromosome 1q; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila);translocated to, 11; protein AF1q

Molecular Weight

Mass (kDA):
10.061 kDA

Genomic Context


Human

Location:	1q21.3
Sequence:	1; NC_000001.11 (151060397..151069544)

Tissue Specificity

Expressed in myoepithelial cells of normal breast tissue (at protein level) (PubMed:26079538). Highly expressed in thymus (PubMed:7833468). Expressed in colon, small intestine, prostate and ovary. Not detected in peripheral blood lymphocytes and spleen (PubMed:7833468).

Subcellular Localizations

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Continuous nuclear export is followed by degradation.

Diseases

Leukemia
Malignant Neoplasms
Leukemia, Myelocytic, Acute
Neoplasms
Myeloid Leukemia
Chromosomal Translocation
Malignant Neoplasm Of Breast
Neoplasm Metastasis
Carcinoma
Mammary Neoplasms
Malignant Squamous Cell Neoplasm
Leukemogenesis

Cell Transformation, Neoplastic
Acute Myelomonocytic Leukemia
Myelomonocytic Leukemia
Adult Acute Myeloblastic Leukemia
Embryonal Carcinoma
Lymphocytic Neoplasm
Metastatic Malignant Neoplasm To The Lung

Interacting Proteins

TCF7

Pathways

Gene Silencing
Notch Signaling Pathway
Drug Resistance
Membrane Depolarization
Cell Death
Immune Response
Pathogenesis
Nuclear Export

Rna Interference
Localization

PTMs

Phosphoprotein

Ubl conjugation

Research Areas

Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MLLT11

References

PMID: 7833468 by Tse W., et al. A novel gene, AF1q, fused to MLL in t(1;11)(q21;q23), is specifically expressed in leukemic and immature hematopoietic cells.

PMID: 21715312 by Parcelier A., et al. AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway.