This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Myeloid leukemia factor 1 Antibodies
AND MLF1 ELISA kits, Myeloid leukemia factor 1 Proteins
Many biological assays use antibodies to detect Myeloid leukemia factor 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Myeloid leukemia factor 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Myeloid leukemia factor 1 antibodies...
Previous: CBLIF
Next: MAP3K9
MLF1 Infographic by Boster Bio
All MLF1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, WB
$523
Cat # M06772-2
100 µl
Cat # M06772-2
100 µl
Human
$628
Cat # LS004291
100 µg
Cat # LS004291
100 µg
MLF1 Overview
Facts about Myeloid leukemia factor 1.
Myeloid leukemia factor 1 (MLF1)
Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels.
Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of numerous genes so may function as a transcription factor in the nucleus.
Gene Information
| Human | |
|---|---|
| Gene Name: | MLF1 |
| Uniprot: | P58340 |
| Entrez: | 4291 |
Family
| Belongs to: |
|---|
| MLF family |
Alternative Names
Myelodysplasia-myeloid leukemia factor 1; myeloid leukemia factor 1
Molecular Weight
Mass (kDA):
30.627 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q25.32 |
| Sequence: | 3; NC_000003.12 (158571163..158606456) |
Tissue Specificity
Most abundant in testis, ovary, skeletal muscle, heart, kidney and colon. Low expression in spleen, thymus and peripheral blood leukocytes.
Subcellular Localizations
Cytoplasm. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Shuttles between the cytoplasm and nucleus.
Diseases
- Leukemia
- Myeloid Leukemia
- Leukemia, Myelocytic, Acute
- Chromosomal Translocation
- Malignant Neoplasms
- Neoplasms
- Dysmyelopoietic Syndromes
- Acute Erythroblastic Leukemia
- Cytogenetic Abnormality
- Malignant Paraganglionic Neoplasm
- Carcinogenesis
- Cell Transformation, Neoplastic
Interacting Proteins
- DNAJB6
- MAGEA11
- PSMD2
- YWHAE
Pathways
- Localization
- Nuclear Export
- Methylation
- Transport
- Cell Cycle Arrest
- Cell Cycle
- Senescence
- Cell Death
- Pathogenesis
- Cell Adhesion
- Programmed Cell Death
- Cellular Senescence
- Proteolysis
PTMs
- Methylation
Research Areas
- Cancer
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MLF1
bosterbio.com/bosterbio-gene-info-cards/MLF1
References
PMID: 8570204 by Yoneda-Kato N., et al. The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.
PMID: 15116101 by Hanissian S.H., et al. cDNA cloning and characterization of a novel gene encoding the MLF1- interacting protein MLF1IP.