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MAP3K9 Antibodies
AND MAP3K9 ELISA kits, MAP3K9 Proteins
Many biological assays use antibodies to detect MAP3K9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP3K9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP3K9 antibodies...
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MAP3K9 Overview
Facts about Mitogen-activated protein kinase kinase kinase 9.
Mitogen-activated protein kinase kinase kinase 9 (MAP3K9)
Serine/threonine kinase which functions as an essential component of the MAP kinase signal transduction pathway. Plays an essential role in the cascades of cellular responses evoked by changes in the environment.
Once activated, functions as an upstream activator of the MKK/JNK signal transduction cascade throughout the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors.
Gene Information
| Human | |
|---|---|
| Gene Name: | MAP3K9 |
| Uniprot: | P80192 |
| Entrez: | 4293 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.25; MEKK9; mitogen-activated protein kinase kinase kinase 9; MLK1Mixed lineage kinase 1; PRKE1mixed lineage kinase 1 (tyr and ser/thr specificity)
Molecular Weight
Mass (kDA):
121.895 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q24.2 |
| Sequence: | 14; NC_000014.9 (70722526..70809513, complement) |
Tissue Specificity
Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.
Diseases
- Malignant Neoplasms
- Neurodegenerative Disorders
- Neoplasms
- Inflammation
- Malignant Tumor Of Colon
- Nervousness
- Cholangiocarcinoma
- Melanoma
- Colonic Neoplasms
- Inflammatory Response
- Parkinson Disease
- Carcinoma
Interacting Proteins
- HSP90AB1
Pathways
- Cell Proliferation
- Cell Death
- Cell Growth
- Bioluminescence
- Reverse Transcription
- Cytokine Production
- Programmed Cell Death
- Cell Cycle
- Dorsal Closure
PTMs
Research Areas
- GPCR
- MAP Kinase Signaling
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP3K9
bosterbio.com/bosterbio-gene-info-cards/MAP3K9
References
PMID: 15610029 by Durkin J.T., et al. Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop.
PMID: 8477742 by Dorow D.S., et al. Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains.