Membrane protein MLC1 Antibodies

AND MLC1 ELISA kits, Membrane protein MLC1 Proteins

Many biological assays use antibodies to detect Membrane protein MLC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Membrane protein MLC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Membrane protein MLC1 antibodies...

We validate the specificity of these antibodies to Membrane protein MLC1 by testing them on tissues known to express MLC1 positively and negatively. Browse below to find the MLC1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MLC1 Infographic by Boster Bio

All MLC1 Products

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Product

Figures

Specificity

Applications

Price

Anti-MLC1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A02920-1
100 μg/vial

MLC1 (NM_015166) Human Over-expression Lysate

Human

$628
Cat # LS023209
100 µg

MLC1 Overview

Facts about Membrane protein MLC1.

MLC1 3D structure. Source: alphafold

Membrane protein MLC1 (MLC1)

Regulates the response of astrocytes to hypo-osmosis by boosting calcium influx. .

Gene Information

Human
Gene Name:	MLC1
Uniprot:	Q15049
Entrez:	23209

Family

Belongs to:

No superfamily

Alternative Names

LVM; megalencephalic leukoencephalopathy with subcortical cysts 1; WKL1

Molecular Weight

Mass (kDA):
41.141 kDA

Genomic Context


Human

Location:	22q13.33
Sequence:	22; NC_000022.11 (50059391..50085875, complement)

Tissue Specificity

Expressed in the brain, with highest levels found in the amygdala, nucleus caudatus, thalamus and hippocampus.

Subcellular Localizations

Membrane; Multi-pass membrane protein. Cell membrane. Cytoplasm, perinuclear region. Endoplasmic reticulum.

Diseases

Leukoencephalopathies
Megalencephalic Leukoencephalopathy With Subcortical Cysts
Macrocephaly
Central Nervous System Cysts
Leukodystrophy
Dementia, Vascular
Brain Diseases
Ataxia
Schizophrenia
Muscle Spasticity
Catatonia
Schizophrenia, Catatonic

Alexander Disease
Epilepsy
Nervous System Disorder
Impaired Cognition
Infarction
Myocardial Infarction

Pathways

Localization
Cytokinesis
Transport
Cell Cycle
Cell Division
Pathogenesis
Methylation
Translation
Proteolysis
Dna Methylation
Synaptic Transmission
Endocytosis
Ion Homeostasis

Secretion
Cleavage Furrow Ingression
Cell Adhesion
Hibernation
Hyphal Growth
Electron Transport
Electron Transport Chain

PTMs

Phosphorylation
Cleavage
Methylation
Nitrosylation
Nitration

Sumoylation
Demethylation
Acetylation
Prenylation
Acylation

Palmitoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MLC1

References

PMID: 11326298 by Meyer J., et al. A missense mutation in a novel gene encoding a putative cation channel is associated with catatonic schizophrenia in a large pedigree.

PMID: 22328087 by Lanciotti A., et al. Megalencephalic leukoencephalopathy with subcortical cysts protein 1 functionally cooperates with the TRPV4 cation channel to activate the response of astrocytes to osmotic stress: dysregulation by pathological mutations.