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JMJD6 Antibodies
AND JMJD6 ELISA kits, JMJD6 Proteins
Many biological assays use antibodies to detect JMJD6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with JMJD6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop JMJD6 antibodies...
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JMJD6 Infographic by Boster Bio
All JMJD6 Products
Product
Figures
Specificity
Applications
Price
Bovine, Human, Mouse, Rat
IF, IHC, WB
$399
Cat # A03690
100μl
Cat # A03690
100μl
JMJD6 Overview
Facts about Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6.
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6)
Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase which catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2.
Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Along with peptidyl-lysine 5-dioxygenase activity, may serve as an RNA hydroxylase, as suggested by its ability to bind single strand RNA.
Gene Information
| Human | |
|---|---|
| Gene Name: | JMJD6 |
| Uniprot: | Q6NYC1 |
| Entrez: | 23210 |
Family
| Belongs to: |
|---|
| JMJD6 family |
Alternative Names
bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; EC 1.14.11; EC 1.14.11.-; Histone arginine demethylase JMJD6; JmjC domain-containing protein 6; JMJD6; jumonji domain containing 6; Jumonji domain-containing protein 6; KIAA0585PSR; Lysyl-hydroxylase JMJD6; Peptide-lysine 5-dioxygenase JMJD6; Phosphatidylserine receptorPTDSR; Protein PTDSR; PSR; PTDSR; PTDSR1
Molecular Weight
Mass (kDA):
46.462 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.1 |
| Sequence: | 17; NC_000017.11 (76712830..76726783, complement) |
Tissue Specificity
Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nursing thymic epithelial cells.
Subcellular Localizations
Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm. Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the cell cycle.
Diseases
- Inflammation
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Hypoxia
- Neoplasms
- Asthma
- Tissue Adhesions
- Autoimmune Diseases
- Cystic Fibrosis
- Reperfusion Injury
- Bronchiectasis
- Bronchitis, Chronic
Interacting Proteins
- BRD4
- CARM1
- CDK9
- ESR1
- FRMD6
- NAA50
- PRPF38A
- TP53
- U2AF1
- ZCCHC17
Pathways
- Phagocytosis
- Methylation
- Cell Death
- Demethylation
- Histone Methylation
- Localization
- Pathogenesis
- Programmed Cell Death
- Histone Modification
- Cell Cycle
- Histone Demethylation
- Rna Splicing
- Tissue Homeostasis
PTMs
- Demethylation
- Methylation
- Hydroxylation
- Phosphorylation
Research Areas
- Epigenetics
- Stem Cell Signaling Pathway
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JMJD6
bosterbio.com/bosterbio-gene-info-cards/JMJD6
References
PMID: 14729065 by Cui P., et al. Nuclear localization of the phosphatidylserine receptor protein via multiple nuclear localization signals.
PMID: 15072554 by Cao W.M., et al. Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells.