MKNK2 Antibodies

AND MKNK2 ELISA kits, MKNK2 Proteins

Many biological assays use antibodies to detect MKNK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MKNK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MKNK2 antibodies...

We validate the specificity of these antibodies to MKNK2 by testing them on tissues known to express MKNK2 positively and negatively. Browse below to find the MKNK2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MKNK2 Infographic by Boster Bio

All MKNK2 Products

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Anti-Mnk2 MKNK2 Antibody

6 Q&As

Human, Mouse, Rat

$399
Cat # A03619
100μl

MNK2 (MKNK2) (NM_017572) Human Over-expression Lysate

Human

$628
Cat # LS002872
100 µg

MKNK2 Overview

Facts about MAP kinase-interacting serine/threonine-protein kinase 2.

MKNK2 3D structure. Source: alphafold

MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)

May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein to the 7-methylguanosine-containing mRNA cap.

Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus.

Gene Information

Human
Gene Name:	MKNK2
Uniprot:	Q9HBH9
Entrez:	2872

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.1; G protein-coupled receptor kinase 7; GPRK7Putative map kinase interacting kinase; MAP kinase interacting serine/threonine kinase 2; MAP kinase signal-integrating kinase 2; Mnk2; MNK2MAP kinase-interacting serine/threonine-protein kinase 2

Molecular Weight

Mass (kDA):
51.875 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (2037471..2051278, complement)

Tissue Specificity

Ubiquitously expressed in all tissues examined. Isoform 2 is expressed at higher levels in the ovary than is isoform 1.

Subcellular Localizations

[Isoform 2]: Nucleus, PML body.; [Isoform 1]: Cytoplasm.

Diseases

Malignant Neoplasms
Neoplasms
Cell Transformation, Neoplastic
Leukemia
Acute Promyelocytic Leukemia
Sclerosis
Malignant Neoplasm Of Breast
Von Hippel-lindau Syndrome
Glioma
Carcinoma
Diffuse Scleroderma
Leukemia, Myelocytic, Acute
Usual Interstitial Pneumonitis

Cardiovascular Diseases
Fibrosis
Myeloid Leukemia
Cytoplasmic Accumulation
Mammary Neoplasms
Lymphoma
Cicatrix

Interacting Proteins

MAPK14

Pathways

Translation
Localization
Cell Proliferation
Cell Growth
Nuclear Export
Hyperphosphorylation
Protein Splicing
Mesenchymal Cell Proliferation
Muscle Atrophy
Spermatogenesis
Rna Splicing

Sensitization
Cell Differentiation
Pathogenesis
Pachytene
Nuclear Import
Oncogenesis

PTMs

Phosphorylation
Dephosphorylation

Cleavage
Ubiquitination

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MKNK2

References

PMID: 11013076 by Slentz-Kesler K., et al. Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta.

PMID: 11154262 by Scheper G.C., et al. The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.