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MINPP1 Antibodies
AND MINPP1 ELISA kits, MINPP1 Proteins
Many biological assays use antibodies to detect MINPP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MINPP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MINPP1 antibodies...
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MINPP1 Overview
Facts about Multiple inositol polyphosphate phosphatase 1.
Multiple inositol polyphosphate phosphatase 1 (MINPP1)
Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to generate phospho-D-glycerate without creation of 3- phosphoglycerate.
May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | MINPP1 |
| Uniprot: | Q9UNW1 |
| Entrez: | 9562 |
Family
| Belongs to: |
|---|
| histidine acid phosphatase family |
Alternative Names
EC 3.1.3.62; HIPER1; Inositol (13,4,5)-tetrakisphosphate 3-phosphatase; Ins(13,4,5)P(4) 3-phosphatase; MINPP2; MIPPDKFZp564L2016; multiple inositol polyphosphate histidine phosphatase, 1; multiple inositol polyphosphate phosphatase 1; multiple inositol polyphosphate phosphatase 2; multiple inositol-polyphosphate phosphatase 1
Molecular Weight
Mass (kDA):
55.051 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q23.2 |
| Sequence: | 10; NC_000010.11 (87504466..87553461) |
Tissue Specificity
Widely expressed with highest levels in kidney, liver and placenta.
Subcellular Localizations
Endoplasmic reticulum lumen.
Diseases
- Hyperplasia
- Adenoma
- Hamartoma Syndrome, Multiple
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasms
- Neoplasms
- Benign Neoplasm
- Hyperplastic Polyp
- Juvenile Polyposis Syndrome
- Intestinal Cancer
- Follicular Thyroid Carcinoma
- Polyps
Pathways
- Pathogenesis
- Chondrocyte Differentiation
- Aging
- Cell Growth
- Bone Development
- Chondrocyte Hypertrophy
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MINPP1
bosterbio.com/bosterbio-gene-info-cards/MINPP1
References
PMID: 9923613 by Caffrey J.J., et al. The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up- regulated during endochondral ossification.
PMID: 10087200 by Chi H., et al. Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19.