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Mitofusin-1 Antibodies
AND MFN1 ELISA kits, Mitofusin-1 Proteins
Many biological assays use antibodies to detect Mitofusin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mitofusin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mitofusin-1 antibodies...
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MFN1 Infographic by Boster Bio
All MFN1 Products
Product
Figures
Specificity
Applications
Price
Anti-Mitofusin 1/MFN1 Antibody Picoband®
1 Citations 6 Q&As
Human, Mouse, Rat
WB
$370
Cat # PB9264
100 μg/vial
Cat # PB9264
100 μg/vial
Human
IF, ICC, WB
$370
Cat # M02172-1
100 μg/vial
Cat # M02172-1
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M02172-2
100 µl
Cat # M02172-2
100 µl
MFN1 Overview
Facts about Mitofusin-1.
Mitofusin-1 (MFN1)
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125).
It may involve a significant rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are exceptionally dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376).
Gene Information
| Human | |
|---|---|
| Gene Name: | MFN1 |
| Uniprot: | Q8IWA4 |
| Entrez: | 55669 |
Family
| Belongs to: |
|---|
| TRAFAC class dynamin-like GTPase superfamily |
Alternative Names
DKFZp762F247; EC 3.6.5; EC 3.6.5.-; FLJ20693; Fzo homolog; hfzo1; hfzo2; MFN1; MGC41806; mitochondrial transmembrane GTPase Fzo-1; mitochondrial transmembrane GTPase FZO-2; Mitofusin 1; mitofusin-1; putative transmembrane GTPase; Transmembrane GTPase MFN1
Molecular Weight
Mass (kDA):
84.16 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q26.33 |
| Sequence: | 3; NC_000003.12 (179347709..179394936) |
Tissue Specificity
Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376). Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411).
Subcellular Localizations
Mitochondrion outer membrane; Multi-pass membrane protein.; [Isoform 2]: Cytoplasm.
Diseases
- Atrophy
- Optic Atrophy
- Parkinson Disease
- Nerve Degeneration
- Optic Atrophy, Autosomal Dominant
- Neurodegenerative Disorders
- Charcot-marie-tooth Disease
- Malignant Neoplasms
- Peripheral Neuropathy
- Insulin Resistance
- Alzheimer's Disease
- Physiological Stress
Interacting Proteins
- MAVS
- MFN2
Pathways
- Mitochondrial Fusion
- Mitochondrial Fission
- Cell Death
- Membrane Fusion
- Transport
- Autophagy
- Pathogenesis
- Oxidative Phosphorylation
- Rna Interference
- Localization
- Regulation Of Mitochondrial Fusion
- Electron Transport
- Proteolysis
PTMs
- Phosphorylation
- Ubiquitination
Research Areas
- Cell Biology
- Mitochondrial Fusion Proteins
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MFN1
bosterbio.com/bosterbio-gene-info-cards/MFN1
References
PMID: 11181170 by Santel A., et al. Control of mitochondrial morphology by a human mitofusin.
PMID: 9230308 by Hales K.G., et al. Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase.
1 Publications of Boster Mitofusin-1 Antibodies & ELISA Kits
- PubMed ID: 32884840, Jiao Z,Wu Y,Qu S.Fenpropathrin induces degeneration of dopaminergic neurons via ...
*More publications can be found for each product on its corresponding product page