MEX3C Antibodies

AND MEX3C ELISA kits, MEX3C Proteins

Many biological assays use antibodies to detect MEX3C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MEX3C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MEX3C antibodies...

We validate the specificity of these antibodies to MEX3C by testing them on tissues known to express MEX3C positively and negatively. Browse below to find the MEX3C antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MEX3C Infographic by Boster Bio

All MEX3C Products

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Specificity

Applications

Price

Anti-Rkhd2 MEX3C Antibody

Human, Mouse, Rat

ELISA, WB

$449
Cat # A09281
0.1 mg

Anti-MEX3C Antibody

Human

$405
Cat # A09281-1
100ul

MEX3C Overview

Facts about RNA-binding E3 ubiquitin-protein ligase MEX3C.

MEX3C 3D structure. Source: alphafold

RNA-binding E3 ubiquitin-protein ligase MEX3C (MEX3C)

E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay.

RNA binding is sufficient to stop translation, but ubiquitin ligase activity is required for mRNA degradation. .

Gene Information

Human
Gene Name:	MEX3C
Uniprot:	Q5U5Q3
Entrez:	51320

Family

Belongs to:

No superfamily

Alternative Names

BM-013; FLJ38871; mex-3 homolog C (C. elegans); ring finger and KH domain containing 2; RING finger protein 194; RNA-binding protein MEX3C; RNF194

Molecular Weight

Mass (kDA):
69.366 kDA

Genomic Context


Human

Location:	18q21.2
Sequence:	18; NC_000018.10 (51174550..51197681, complement)

Tissue Specificity

Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine.

Subcellular Localizations

Cytoplasm. Nucleus. Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.

Diseases

Growth Retardation
Hypertensive Disease
Essential Hypertension
Aspergillosis, Allergic Bronchopulmonary
Obesity
Hypertrophy
Anthrax Disease
Steatosis

Dysequilibrium Syndrome
Fatty Liver

Interacting Proteins

USP7

Pathways

Translation
Immune Response
Fatty Acid Oxidation
Excretion
Cell Fate Specification

PTMs

Oxidation

Ubiquitination

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MEX3C

References

PMID: 17267406 by Buchet-Poyau K., et al. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies.

PMID: 17015768 by Guzman B., et al. Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene.