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- Table of Contents
Facts about Homeobox protein Meis2.
Likely in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in collaboration with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain.
Human | |
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Gene Name: | MEIS2 |
Uniprot: | O14770 |
Entrez: | 4212 |
Belongs to: |
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TALE/MEIS homeobox family |
Meis (mouse) homolog 2; Meis homeobox 2; Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse); Meis1-related gene 1; MGC2820; myeloid ecotropic viral integration site 1 homolog 2; TALE homeobox protein Meis2
Mass (kDA):
51.79 kDA
Human | |
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Location: | 15q14 |
Sequence: | 15; NC_000015.10 (36889204..37101311, complement) |
Expressed in various tissues. Expressed at high level in the lymphoid organs of hematopoietic tissues. Also expressed in some regions of the brain, such as the putamen.
Nucleus. Cytoplasm, perinuclear region.
PMID: 10764806 by Yang Y., et al. Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription.
PMID: 9383298 by Smith J.E. Jr., et al. Chromosomal mapping to 15q14 and expression analysis of the human MEIS2 homeobox gene.