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Pyrin Antibodies
AND MEFV ELISA kits, Pyrin Proteins
Many biological assays use antibodies to detect Pyrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pyrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pyrin antibodies...
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MEFV Infographic by Boster Bio
All MEFV Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A00764-1
100 μg/vial
Cat # A00764-1
100 μg/vial
MEFV Overview
Facts about Pyrin.
Pyrin (MEFV)
Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the meeting of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with meeting of the autophagic devices and initiation of autophagy.
Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excess IL1B- and IL18- mediated inflammation (PubMed:16785446, PubMed:17431422, PubMed:26347139). However, it may also have a beneficial impact in the inflammatory pathway.
Gene Information
| Human | |
|---|---|
| Gene Name: | MEFV |
| Uniprot: | O15553 |
| Entrez: | 4210 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FMF; FMFmarenostrin; Marenostrin; Mediterranean fever; MEFpyrin; MGC126560; MGC126586; TRIM20
Molecular Weight
Mass (kDA):
86.444 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (3242027..3256776, complement) |
Tissue Specificity
Expressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesser extent in monocytes but not in lymphocytes. Detected in spleen, lung and muscle, probably as a result of leukocyte infiltration in these tissues. Not expressed in thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, liver, kidney, pancreas. Expression detected in several myeloid leukemic, colon cancer, and prostate cancer cell lines.
Subcellular Localizations
[Isoform 1]: Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection, lamellipodium. Nucleus. Cytoplasm. Cytoplasmic vesicle, autophagosome. Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles. In pre-apoptotic cells, colocalizes with PYCARD/ASC in large specks (inflammasomes). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC.; [Isoform 2]: Nucleus.
Diseases
- Familial Mediterranean Fever
- Brucellosis
- Amyloidosis
- Inflammation
- Arthritis
- Pain
- Asthma
- Abdominal Pain
- Serositis
- Pleurisy
- Airway Obstruction
- Hereditary Diseases
Interacting Proteins
- CASP1
- PSTPIP1
- PYCARD
Pathways
- Pathogenesis
- Localization
- Inflammatory Response
- Secretion
- Aging
- Immune Response
- Reflex
- Innate Immune Response
- Lung Growth
- Cytokine Secretion
- Dna Methylation
- Methylation
- Transport
PTMs
- Cleavage
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MEFV
bosterbio.com/bosterbio-gene-info-cards/MEFV
References
PMID: 9288758 by Aksentijevich I., et al. Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever.
PMID: 11115844 by Papin S., et al. Alternative splicing at the MEFV locus involved in familial Mediterranean fever regulates translocation of the marenostrin/pyrin protein to the nucleus.