MEF2A Antibodies

Myocyte-specific enhancer factor 2A (MEF2A)

Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes.

Mediates mobile functions not only in skeletal and cardiac muscle growth, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or expansion factor-related transcription.

Gene Information

Human
Gene Name:	MEF2A
Uniprot:	Q02078
Entrez:	4205

Family

Belongs to:
MEF2 family

Alternative Names

ADCAD1; MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancerfactor 2A); MEF2; myocyte enhancer factor 2A; myocyte-specific enhancer factor 2A; RSRFC4; RSRFC9; Serum response factor-like protein 1

Molecular Weight

Mass (kDA):
54.811 kDA

Genomic Context

Human
Location:	15q26.3
Sequence:	15; NC_000015.10 (99565417..99716488)

Tissue Specificity

Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined.

Subcellular Localizations

Nucleus.

Diseases

• Hypertrophy
• Coronary Artery Disease
• Myocardial Infarction
• Infarction
• Cardiac Hypertrophy
• Heart Failure
• Cardiomyopathies
• Heart Diseases
• Diabetes Mellitus
• Cardiovascular Diseases
• Atherosclerosis
• Diabetes Mellitus, Experimental
• Inflammation

• Fibrosis
• Nervousness
• Insulin Resistance
• Tissue Adhesions
• Insulin Sensitivity
• Myotonic Dystrophy
• Hypertensive Disease

Interacting Proteins

• MAPK7
• MEOX1
• SUMO1

Pathways

• Cell Differentiation
• Localization
• Regeneration
• Cell Proliferation
• Pathogenesis
• Muscle Cell Differentiation
• Translation
• Heart Development
• Neurogenesis
• Myoblast Differentiation
• Transport
• Cell Cycle
• Nuclear Export

• Hyperphosphorylation
• Glucose Transport
• Neuron Differentiation
• Methylation
• Cell Death
• Rna Interference
• Swimming

PTMs

• Phosphorylation
• Acetylation
• Cleavage
• Methylation
• Sumoylation

• Dephosphorylation
• Deacetylation
• Oxidation
• Demethylation
• Ubiquitination

Research Areas

• Phospho-Specific

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MEF2A

Best Uses Of The MEF2A Marker From Boster Bio

This article will examine Steven Boster and the Polyclonal Anti-MEF2A Marker. This article will also highlight the benefits of using this marker. The MEF2A marker is used for research into cancer and the development of therapeutic drugs. These applications are available to researchers of all sizes regardless of where they are located. It is essential to understand the purpose of these applications before you make any purchases.

Polyclonal Anti-Mef2a Marker

Polyclonal Anti-Mef2-A (Mef2) Marker from Boster Bio is suitable for many different applications. It has a low cross-reactivity with other species, unlike other anti-Mef2 antibodies. Boster Bio Polyclonal Anti-Mef2a Marker is kept at -20°C for one year and can be used for up to six months at a time. The anti-Mef2a marker that is polyclonal is supplied in a solution consisting of 20mM PBS and 50% glycerol. It can be employed in multiplex hybridizations.

Boster scientists are able to submit their research results to applications, special samples or species. Boster scientists can use their results to earn product credits. This policy applies to scientists around the world. Boster scientists are also permitted to submit their results to peer-reviewed journals and scientific conferences. This product is recommended for all scientists. It is a fantastic option for scientists due to its flexibility and sensitive nature.

This antibody targets mef2a and its receptors including Gna13. During the process of regeneration of the heart, Mef2 staining marks the nuclei of cardiomyocytes. This marker is beneficial for studies that investigate the development and function of heart muscle cells. It has a high-titer which allows for a reliable and efficient test.

The polyclonal Anti Mef2A Marker by Boster Bio has been tested clinically and is suitable for the detection of Mef2a and Mef2/Proliferating Cell Nuclear Antigen (PCNA) in various tissues. Its high sensitivity and specificity makes it ideal for research that seek to track the development and function of cardiac myocytes.

Benefits of using the MEF2A Marker

The MEF2A Marker is a lysosomal marker. By using this marker, researchers can determine whether a protein is functioning as intended within a specific cell type. It is a protein which relies on lysosomal or proteasomal mechanisms. Researchers found that MEF2A protein levels were significantly higher in cells that had been treated with H2O2.

Normal aging and neurodegenerative illnesses are both caused by the oxidative stress. MEF2A is a protein that shields neurons from the effects of oxidative stress. However, the precise mechanisms of activation and stability are still unknown. Researchers may be able better understand neurodegenerative diseases by studying the presence of this protein within neurons. Additionally, this protein can help researchers study the possible role of MEF2A in neuronal degeneration, and improve their understanding of neurodegenerative diseases.

Utilizing the MEF2A Marker helps researchers determine how NSCs change into neurons. Neuronal differentiation is the process through which neurons mature. After four days of growth factor withdrawal, MEF2A is found in neurons. Researchers have discovered that MEF2A could play a role in NSC neuron derived neurons. This study will be an important step towards understanding how MEF2A Marker contributes to the formation of neurons and glial cells.

The MEF2A marker is an excellent tool to target diseases that are neoplastic. It can also detect cells that are at risk of developing neurodegenerative diseases. It can also assist in detecting glioma. It's a highly useful tool in a variety of clinical studies. It can be used to determine the impact of different medications in neurodegenerative disorders.

By finding the MEF2A protein It allows you to observe the effects of oxidative stress. Induced oxidative stress will reduce the level of intact lysosomes. However, oxidative stress may result in lysosomal destabilization as well as accumulation of nonfunctional MEF2A. This could also impact the severity of neurodegenerative diseases. MEF2A was discovered to be able to bind the oxidative stress-induced protein through studies of cell death and lysosomal integrity.

Researchers have discovered that MEF2A enhances neuronal lineage. By targeting MEF2A, researchers are able to better understand which NSCs are at the right position for neuronal differentiation. Further research is needed to determine if these proteins serve as therapeutic targets for these diseases. If these studies are successful, MEF2A will be a useful tool to aid in the development of neurons. However the benefits of using the MEF2A Marker are worth the investment.