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- Table of Contents
1 Q&As
Facts about Mediator of RNA polymerase II transcription subunit 13-like.
Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.
Human | |
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Gene Name: | MED13L |
Uniprot: | Q71F56 |
Entrez: | 23389 |
Belongs to: |
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Mediator complex subunit 13 family |
Mediator of RNA polymerase II transcription subunit 13-like
Mass (kDA):
242.602 kDA
Human | |
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Location: | 12q24.21 |
Sequence: | 12; NC_000012.12 (115958576..116277693, complement) |
Highly expressed in brain (cerebellum), heart (aorta), skeletal muscle, kidney, placenta and peripheral blood leukocytes. Highly expressed in fetal brain.
Nucleus.
PMID: 14638541 by Muncke N., et al. Missense mutations and gene interruption in PROSIT240, a novel TRAP240-like gene, in patients with congenital heart defect (transposition of the great arteries).
PMID: 15145061 by Musante L., et al. cDNA cloning and characterization of the human THRAP2 gene which maps to chromosome 12q24, and its mouse ortholog Thrap2.