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Mdga1 Antibodies
AND Mdga1 ELISA kits, Mdga1 Proteins
Many biological assays use antibodies to detect Mdga1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mdga1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mdga1 antibodies...
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Mdga1 Overview
Facts about MAM domain-containing glycosylphosphatidylinositol anchor protein 1.
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (Mdga1)
Required for radial migration of cortical neurons in the superficial layer of the neocortex. Plays a role in the creation or maintenance of inhibitory synapses.
May function by inhibiting the action of NLGN2. .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Mdga1 |
| Uniprot: | Q0PMG2 |
| Entrez: | 74762 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
FLJ45018; GPIM; MAM domain containing glycosylphosphatidylinositol anchor 1; MAMDC3; MDGA1
Molecular Weight
Mass (kDA):
106.047 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 17|17 A3.3 |
| Sequence: | 17; |
Tissue Specificity
Expressed by neurons in layers 2 and 3 of the cortex during their migration and settling in the cortical plate. Also found in layers 4 and 6a. From E9.5-E13.5, detected in the marginal zone of the developing cortex. At E16.5, modest expression is found in the intermediate zone. At postnatal day 0, evident in the superficial cortical plate. By postnatal day 7, expression is limited to layers 2 and 3 throughout most of the cortex.
Diseases
- Tissue Adhesions
- Neoplasms
- Schizophrenia
- Malignant Neoplasms
- Nervousness
- Malignant Bone Neoplasm
- Allelic Imbalance
- Tumor Progression
- Bone Neoplasms
- Malignant Paraganglionic Neoplasm
Pathways
- Cell Adhesion
- Cell Migration
- Secretory Pathway
- Axon Guidance
- Cell Cycle
- Cell Motility
- Brain Development
- Forebrain Development
PTMs
- Gpi Anchoring
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Mdga1
bosterbio.com/bosterbio-gene-info-cards/Mdga1
References
PMID: 16641224 by Takeuchi A., et al. Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1.
PMID: 16959869 by Takeuchi A., et al. Novel IgCAM, MDGA1, expressed in unique cortical area- and layer- specific patterns and transiently by distinct forebrain populations of Cajal-Retzius neurons.