Mucolipin-3 Antibodies

AND MCOLN3 ELISA kits, Mucolipin-3 Proteins

Many biological assays use antibodies to detect Mucolipin-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Mucolipin-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Mucolipin-3 antibodies...

We validate the specificity of these antibodies to Mucolipin-3 by testing them on tissues known to express MCOLN3 positively and negatively. Browse below to find the MCOLN3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MCOLN3 Infographic by Boster Bio

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Mucolipin 3 (MCOLN3) (NM_018298) Human Over-expression Lysate

Human

$960
Cat # LS055283
100 µg

MCOLN3 Overview

Facts about Mucolipin-3.

MCOLN3 3D structure. Source: alphafold

Mucolipin-3 (MCOLN3)

Nonselective ligand-gated cation channel likely playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414).

Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion from the endosomal pathway (PubMed:21245134). Does not appear to serve as mechanosensory transduction channel in inner ear sensory hair cells.

Gene Information

Human
Gene Name:	MCOLN3
Uniprot:	Q8TDD5
Entrez:	55283

Family

Belongs to:

transient receptor (TC 1.A.4) family

Alternative Names

FLJ11006; FLJ36629; MGC71509; mucolipin 3; mucolipin-3; TRPML3; TRP-ML3

Molecular Weight

Mass (kDA):
64.248 kDA

Genomic Context


Human

Location:	1p22.3
Sequence:	1; NC_000001.11 (85018082..85048902, complement)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane. Recycles between the plasma membrane and intracellular compartments by a dynamin-dependent endocytic pathway (PubMed:19522758). Under normal conditions, only a very minor proportion is present at the cell membrane (PubMed:19522758). In the cochlea located at the base of stereocilia near the position of the ankle links (By similarity).