Proto-oncogene DBL Antibodies

AND MCF2 ELISA kits, Proto-oncogene DBL Proteins

Many biological assays use antibodies to detect Proto-oncogene DBL, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Proto-oncogene DBL in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Proto-oncogene DBL antibodies...

We validate the specificity of these antibodies to Proto-oncogene DBL by testing them on tissues known to express MCF2 positively and negatively. Browse below to find the MCF2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MCF2 Infographic by Boster Bio

All MCF2 Products

Product

Figures

Specificity

Applications

Price

Anti-Proto-oncogene DBL MCF2 Antibody

Human, Mouse

$405
Cat # A05775
100ul

Anti-MCF2 Mouse Monoclonal Antibody [Clone ID: OTI2C12]

Human

IHC, WB

$523
Cat # M05775
100 µl

Anti-DBL Antibody Picoband™

Human

ELISA, Flow Cytometry, WB

$370
Cat # A05775-1
100 µg/vial

MCF2 Overview

Facts about Proto-oncogene DBL.

MCF2 3D structure. Source: alphafold

Proto-oncogene DBL (MCF2)

Guanine nucleotide exchange factor (GEF) that governs the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form.

Isoform 1 exhibits no action toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42.

Gene Information

Human
Gene Name:	MCF2
Uniprot:	P10911
Entrez:	4168

Family

Belongs to:

MCF2 family

Alternative Names

ARHGEF21; DBL; MCF 2; MCF.2 cell line derived transforming sequence; MCF2 MCF.2 cell line derived transforming sequence; MCF-2

Molecular Weight

Mass (kDA):
107.673 kDA

Genomic Context


Human

Location:	Xq27.1
Sequence:	X; NC_000023.11 (139581768..139708279, complement)

Tissue Specificity

Isoform 1 is expressed only in brain. Isoform 3 is expressed in heart, kidney, spleen, liver and testis. Isoform 4 is expressed in brain, heart, kidney, testis, placenta, stomach and peripheral blood. The protein is detectable in brain, heart, kidney, intestine, muscle, lung and testis.

Subcellular Localizations

Cytoplasm.; [Isoform 1]: Membrane.; [Isoform 3]: Membrane. Colocalizes with CDC42 to plasma membrane.

Diseases

Cell Transformation, Neoplastic
Neoplasms
Metaplastic Cell Transformation
Tissue Adhesions
Malignant Neoplasm Of Breast
Sarcoma
Malignant Neoplasms
Carcinoma
Lymphoma
Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
Malignant Catarrhal Fever
B-cell Lymphomas
Neoplasms, Experimental

Malignant Paraganglionic Neoplasm
Mammary Neoplasms
Neuroectodermal Tumors
Melanoma
Dysplasia
Neuroblastoma
Synovial Sarcoma

Interacting Proteins

NME1

Pathways

Localization
Cell Growth
Cell Cycle
Cell Migration
Coagulation
Cell Adhesion
Cytoskeleton Organization
Cell Motility
Actin Cytoskeleton Organization
Cell Proliferation
Cell Death
Aging
Fertilization

Proteolysis
Neurogenesis
Ossification
Vasculogenesis
Chromosome Segregation
Anaphase
Cell Cycle Arrest

PTMs

Phosphorylation
Prenylation

Ubiquitination
Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCF2

References

PMID: 3056717 by Ron D., et al. Molecular cloning and characterization of the human dbl proto- oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.

PMID: 12445822 by Komai K., et al. Alternative splicing variants of the human DBL (MCF-2) proto- oncogene.