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MCAM Antibodies
AND MCAM ELISA kits, MCAM Proteins
Many biological assays use antibodies to detect MCAM, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MCAM in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MCAM antibodies...
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MCAM Infographic by Boster Bio
All MCAM Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC
$486
Cat # M01683
100ug/vial
Cat # M01683
100ug/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01683-1
100 μl
Cat # M01683-1
100 μl
Human
ELISA
$499
Cat # EK1675
96 wells/kit, with removable strips.
Cat # EK1675
96 wells/kit, with removable strips.
Human
Flow Cytometry, IHC, IHC-F, WB
$370
Cat # M01683-3
100 μg/vial
Cat # M01683-3
100 μg/vial
Human
IHC, IHC-F, WB
$370
Cat # M01683-4
100 μg/vial
Cat # M01683-4
100 μg/vial
Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, WB
$370
Cat # A01683
100 μg/vial
Cat # A01683
100 μg/vial
MCAM Overview
Facts about Cell surface glycoprotein MUC18.
Cell surface glycoprotein MUC18 (MCAM)
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with mobile elements of the circulatory system, thus enhancing hematogeneous tumor spread.
Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that activates tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Gene Information
| Human | |
|---|---|
| Gene Name: | MCAM |
| Uniprot: | P43121 |
| Entrez: | 4162 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD146 antigen; CD146; cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; L-Gicerin; MCAM; melanoma adhesion molecule; melanoma cell adhesion moleculeS-endo 1 endothelial-associated antigen; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; MUC18; MUC18Gicerin
Molecular Weight
Mass (kDA):
71.607 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.3 |
| Sequence: | 11; NC_000011.10 (119305759..119317130, complement) |
Tissue Specificity
Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Tissue Adhesions
- Melanoma
- Neoplasms
- Neoplasm Metastasis
- Malignant Neoplasms
- Malignant Paraganglionic Neoplasm
- Cell Invasion
- Carcinoma
- Tumor Progression
- Metastatic Melanoma
- Tumor Angiogenesis
- Neoplasm Invasiveness
Pathways
- Cell Adhesion
- Angiogenesis
- Methylation
- Dna Methylation
- Regeneration
- Cell Migration
- Cell-cell Adhesion
- Cell Proliferation
- Pathogenesis
- Cell Growth
- Rna Interference
- Secretion
- Cell Motility
PTMs
- Phosphorylation
- Methylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCAM
bosterbio.com/bosterbio-gene-info-cards/MCAM
References
PMID: 2602381 by Lehmann J.M., et al. MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily.
PMID: 8378324 by Sers C., et al. Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains.