MBTPS2 Antibodies

AND MBTPS2 ELISA kits, MBTPS2 Proteins

Many biological assays use antibodies to detect MBTPS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MBTPS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MBTPS2 antibodies...

We validate the specificity of these antibodies to MBTPS2 by testing them on tissues known to express MBTPS2 positively and negatively. Browse below to find the MBTPS2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MBTPS2 Infographic by Boster Bio

All MBTPS2 Products

Product

Figures

Specificity

Applications

Price

Anti-MBTPS2/S2P Antibody

5 Q&As

Human, Mouse, Rat

ELISA, IF, ICC

$335
Cat # A07369-1
100ul

Anti-MBTPS2 Antibody

Human, Mouse

$405
Cat # A07369
100ul

S2P (MBTPS2) (NM_015884) Human Over-expression Lysate

Human

$960
Cat # LS051360
100 µg

MBTPS2 Overview

Facts about Membrane-bound transcription factor site-2 protease.

MBTPS2 3D structure. Source: alphafold

Membrane-bound transcription factor site-2 protease (MBTPS2)

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Gene Information

Human
Gene Name:	MBTPS2
Uniprot:	O43462
Entrez:	51360

Family

Belongs to:

peptidase M50A family

Alternative Names

EC 3.4.24.85; Endopeptidase S2P; FLJ32174; membrane-bound transcription factor peptidase, site 2; membrane-bound transcription factor protease, site 2; membrane-bound transcription factor site-2 protease; S2PIFAP; SREBPs intramembrane protease; Sterol regulatory element-binding proteins intramembrane protease

Molecular Weight

Mass (kDA):
57.444 kDA

Genomic Context


Human

Location:	Xp22.12
Sequence:	X; NC_000023.11 (21839617..21885423)

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas.

Subcellular Localizations

Membrane; Multi-pass membrane protein. Cytoplasm.

Diseases

Photophobia
Ichthyoses
Atrichia
Endoplasmic Reticulum Stress
Skin Diseases, Genetic
Hereditary Diseases
Dystrophy
Keratosis
Keratosis Follicularis
Dystrophia Unguium
Hyperkeratosis

Malignant Neoplasms
Keratosis Pilaris Decalvans
Liposarcoma
Hypotrichosis
Entamoebiasis
Ichthyosis, X-linked

Pathways

Proteolysis
Cholesterol Homeostasis
Cell Death
Cell Proliferation
Lactation
Dna Demethylation
Dna Methylation
Glycosylation
Demethylation
Methylation

Mrna Splicing
Phagocytosis
Lipid Homeostasis
Interphase
Autophagy

PTMs

Cleavage
Phosphorylation

Demethylation
Glycosylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MBTPS2

References

PMID: 9659902 by Rawson R.B., et al. Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs.

PMID: 10419520 by Zelenski N.G., et al. Membrane topology of S2P, a protein required for intramembranous cleavage of sterol regulatory element-binding proteins.