MBNL2 Antibodies

AND MBNL2 ELISA kits, MBNL2 Proteins

Many biological assays use antibodies to detect MBNL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MBNL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MBNL2 antibodies...

We validate the specificity of these antibodies to MBNL2 by testing them on tissues known to express MBNL2 positively and negatively. Browse below to find the MBNL2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MBNL2 Infographic by Boster Bio

All MBNL2 Products

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Specificity

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Price

MBNL2 (NM_207304) Human Recombinant Protein

$813
Cat # PROTQ5VZF2
20 µg

MBNL2 (NM_144778) Human Over-expression Lysate

Human

$628
Cat # LS010150
100 µg

MBNL2 Overview

Facts about Muscleblind-like protein 2.

MBNL2 3D structure. Source: alphafold

Muscleblind-like protein 2 (MBNL2)

Acts either as activator or repressor of splicing on particular pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle.

Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein which binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3.

Gene Information

Human
Gene Name:	MBNL2
Uniprot:	Q5VZF2
Entrez:	10150

Family

Belongs to:

muscleblind family

Alternative Names

DKFZp781H1296; MBLL39Muscleblind-like protein 1; MBLLMGC120628; MGC120625; MGC120626; MLP1; muscleblind-like 2 (Drosophila); muscleblind-like protein 2; Muscleblind-like protein-like 39; Muscleblind-like protein-like; PRO2032

Molecular Weight

Mass (kDA):
40.518 kDA

Genomic Context


Human

Location:	13q32.1
Sequence:	13; NC_000013.11 (97222289..97394120)

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Subcellular Localizations

Nucleus. Cytoplasm. Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques (PubMed:16273094). Location in the cytoplasm is microtubule-dependent (PubMed:16273094). In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts (PubMed:11929853).

Diseases

Myotonic Dystrophy
Dystrophy
Trinucleotide Repeat Expansion
Myopathy
Muscular Dystrophy
Dystrophia Myotonica 2
Nervousness
Tissue Adhesions
Intraepithelial Neoplasia
Macule
Weakness
Uterine Cervical Neoplasm

Muscular Dystrophy, Duchenne
Dystrophia Myotonica 1
Malignant Tumor Of Cervix
Malignant Neoplasms
Neoplasms
Cervical Intraepithelial Neoplasia

Pathways

Pathogenesis
Localization
Rna Splicing
Eye Development
Circadian Rhythm
Synaptic Transmission
Mrna Destabilization
Cell Fate Determination
Protein Secretion
Rna Localization

Mrna Splicing
Translation
Rna Processing
Heart Development
Secretion

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MBNL2

References

PMID: 16273094 by Adereth Y., et al. RNA-dependent integrin alpha3 protein localization regulated by the muscleblind-like protein MLP1.

PMID: 11929853 by Fardaei M., et al. Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells.