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- Table of Contents
Facts about MAP3K12-binding inhibitory protein 1.
Inhibits the MAP3K12 Action to induce the activation of This JNK/SAPK pathway.
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4..
Human | |
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Gene Name: | MBIP |
Uniprot: | Q9NS73 |
Entrez: | 51562 |
Belongs to: |
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No superfamily |
MAP3K12 binding inhibitory protein 1; MAP3K12-binding inhibitory protein 1; MAPK upstream kinase-binding inhibitory protein; MUK-binding inhibitory protein
Mass (kDA):
39.281 kDA
Human | |
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Location: | 14q13.3 |
Sequence: | 14; NC_000014.9 (36298558..36320676, complement) |
Ubiquitous. High expression seen in the heart and lung.
Nucleus. Cytoplasm. Shows a cytoplasmic localization when coexpressed with MAP3K12.
PMID: 10801814 by Fukuyama K., et al. MAPK upstream kinase (MUK)-binding inhibitory protein, a negative regulator of MUK/Dual leucine zipper-bearing kinase/leucine zipper protein kinase.
PMID: 19103755 by Guelman S., et al. The double-histone-acetyltransferase complex ATAC is essential for mammalian development.