MBD1 Antibodies

Methyl-CpG-binding domain protein 1 (MBD1)

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that's made by DNA damage by methylmethanesulfonate (MMS).

Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which subsequently recruits factors like the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone'Lys-9' trimethylation.

Gene Information

Human
Gene Name:	MBD1
Uniprot:	Q9UIS9
Entrez:	4152

Family

Belongs to:
No superfamily

Alternative Names

CXXC-type zinc finger protein 3; methyl-CpG binding domain protein 1 isoform PCM1; methyl-CpG binding domain protein 1; methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; PCM1CXXC3RFT; Protein containing methyl-CpG-binding domain 1; the regulator of fibroblast growth factor 2 (FGF-2) transcription

Molecular Weight

Mass (kDA):
66.607 kDA

Genomic Context

Human
Location:	18q21.1
Sequence:	18; NC_000018.10 (50266882..50281774, complement)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Nucleus. Nucleus matrix. Nucleus speckle. Chromosome. Colocalizes with the Ten-1 ICD form of TENM1 in foci associated with the nuclear matrix (By similarity). Nuclear, in a punctate pattern. Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes.

Diseases

• Metabolic Bone Disorder
• Malignant Neoplasms
• Neoplasms
• Rett Syndrome
• Carcinoma
• Cell Transformation, Neoplastic
• Malignant Neoplasm Of Lung
• Lung Neoplasms
• Malignant Neoplasm Of Breast
• Prostatic Neoplasms
• Autistic Disorder
• Carcinogenesis

• Hepatitis B
• Hepatitis
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Pancreas
• Malignant Neoplasm Of Prostate
• Cytomegalovirus Infections
• Pancreatic Neoplasm

Interacting Proteins

• CBX5
• CHAF1A
• HDAC1
• HDAC2
• HDAC3

• HTT
• PIAS1
• PIAS3
• SETDB1
• SUMO1

• SUV39H1

Pathways

• Methylation
• Dna Methylation
• Gene Silencing
• Localization
• Demethylation
• Rna Interference
• Histone Modification
• Regulation Of Gene Expression
• Cell Differentiation
• Histone Acetylation
• Histone Methylation
• Chromatin Remodeling
• Histone Deacetylation

• Dna Repair
• Pathogenesis
• Neurogenesis
• Cell Proliferation
• Dna Replication
• Dna Hypermethylation
• Brain Development

PTMs

• Methylation
• Acetylation
• Deacetylation
• Demethylation
• Phosphorylation

• Sumoylation
• Cleavage
• Oxidation
• Reduction
• Dephosphorylation

Research Areas

• Chromatin Research

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MBD1

Best Uses Of The MBD1 Marker

The MBD1 marker is a protein that is found in numerous cells, including those in the brain and has a number of different applications. The protein is utilized by researchers to study the function and structure of these cells. Numerous studies have proven that these antibodies are very efficient in a range of applications including tumor research and cellular immunity. For more information, go to the Boster Bio website. The following articles offer more information about the MBD1 marker.

Boster Bio: Anti-KHDRBS2 Antibody

Boster Bio's Anti-KHDRBS2 Antibody recognizes MBD1 as a target in cell culture, Western blot, and immunohistochemistry. This antibody is purified , and tested in a variety applications. In contrast to other antibodies, this one recognizes the MBD1 marker that is found in Human cells. In addition to its high affinity and specificity the antibody can be used for a variety of applications, including immunohistochemistry as well as IP.

Boster Bio: Anti-MBD1 Antibody

The MBD1 marker refers to the binding of a protein to an endocrine receptor. This permits scientists to target this protein and study the cellular composition of a specific type of cell or tissue. It is located in the brain and the trachea. It is mostly nuclear in nature and its location is determined by the tissue it's located in.