Matrilin-2 Antibodies

Matrilin-2 (MATN2)

Involved in matrix assembly. .

.

Gene Information

Human
Gene Name:	MATN2
Uniprot:	O00339
Entrez:	4147

Family

Belongs to:
No superfamily

Alternative Names

MATN2; matrilin 2; Matrilin2; Matrilin-2

Molecular Weight

Mass (kDA):
106.837 kDA

Genomic Context

Human
Location:	8q22.1-q22.2
Sequence:	8; NC_000008.11 (97869064..98036724)

Subcellular Localizations

Secreted.

Diseases

• Von Willebrand Disease
• Carcinoma
• Carcinogenesis
• Malignant Neoplasms
• Neoplasms
• Nervousness
• Hypertrophy
• Stromal Corneal Dystrophy
• Liver Diseases
• Peripheral Nerve Injuries
• Tumor Progression
• Glaucoma, Open-angle

• Neoplasm Invasiveness
• Tumor-associated Vasculature
• Fibrosis
• Aqueous Humor Disorders
• Liver Regeneration Disorder
• Plaque, Amyloid
• Primary Open Angle Glaucoma

Interacting Proteins

• ATXN7
• CACNA1A

Pathways

• Regeneration
• Cell Proliferation
• Cell Migration
• Wound Healing
• Secretory Pathway
• Response To Wounding
• Osteoblast Differentiation
• Proteolysis
• Glycosylation
• Localization
• Myelination
• Schwann Cell Proliferation
• Neuroprotection

• Keratinocyte Migration
• Reverse Transcription
• Tissue Remodeling
• Liver Regeneration
• Cell Growth
• Pathogenesis
• Extracellular Matrix Assembly

PTMs

• Cleavage

• Reduction

• Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MATN2

Boster Bio - Anti-Matrilin-2 MATP2 Antibody and Validation Protocols

This article will discuss the Boster BIO: Anti-Matrilin-2 MaTN2 Antibody, and its Validation Protocols. It will also discuss the uses of MATN2 antibodies. Boster also recognizes the importance of unbiased research. Boster pays royalties to first reviewers of their products, and offers them product credits. This allows scientists from around the world, to review and assess products.

Boster Bio: Anti-Matrilin-2 MATN2 Antibody

The Boster Bio Anti-Matrilin-2 MATP2 Antibody is a monoclonal antibody that detects all forms of matrilin-2 in human, mouse and rat cells. The antibody was made using Western Blot (WB) and tested for specificity in rat, mouse and human tissue.

Boster Bio, which is the manufacturer of this antibody, is well-known for providing high quality antibodies for research. They have been in the business of developing high-specificity, sensitive, and high-affinity antibodies for over two decades. More than 29,000 publications cite their products. Boster Bio Anti-Matrilin-2 MATN2 Antibody can be used in many research projects.

MATN2 can be described as a non-collagenous, extracellular matrix protein. It is part of the von Willebrand superfamily and is thought that it participates in the formation fibrilous networks in various tissues. There are two variants of Matrilin-2's genetic code. Each encodes a different type of Matrilin-2. The product is not available online. You may contact Boster Bio for more information about this product.

Matrilin-2 is expressed in nonskeletal tissues, including the stomach and the kidney. It is also found in the basement membranes of distal convoluted tubes and in human salivary glands. It is thought that it is a crucial protein in the communication between epithelia and the extracellular matrix. Matrilin-2 Antibody is used to support research projects by identifying the presence of this protein within these tissues and quantifying its quantity.

Boster Bio Anti-Matrillin-2 Mass Spec Antibody (MATN2) was created for research purposes to detect matrilin-2 from human cell lines. It is designed to target both CD44+CD24 breast cancer stem cells and mRNA-expressed human breast cancer cells. It is able to interact with these cell types, including breast cancer cells, because of its high affinity for the receptor.

Boster Bio: AntiMatrillin-2 MaTN2 Polyclonal

Boster Bio Validation Protocols

Boster Bio Validation Protocols are important to understand the expectations of your product before ordering. Boster Biological Technology is required to notify you if a product arrives damaged within 12 months. Boster Biological Technology will review all details of the Customer’s Protocol to determine if there is a problem with the protocol. If it is, Boster Bio will offer a refund or replacement. If the product does not meet your expectations, Boster Bio may not be able to issue a refund.

ELISA involves many variables, such as the antibody concentration, sample preparation and blocking buffer. Boster Bio offers a variety optimization tips to help you choose and optimize the antibodies that you use. Boster Bio also offers a ELISA optimization manual that will answer all your questions and give you the right solutions to achieve the best results. Boster Bio Validation Protocols are a great resource for anyone who is unfamiliar with ELISA. They will help you conduct the most reproducible and accurate experiments.

You should inspect the product immediately upon receipt for any damage. Boster Biology Technology must be notified of any shortage or defect within seven working days. Incorrect products are not covered by the policy. Custom Products, hazardous products and customized orders are exempted from this policy. For more information, please visit the Boster Biological Technologies website. If you have any questions or concerns, contact Boster Biological Technology. When purchasing Boster Bio Validation Protocols, you can rely on Boster Biological Technology to deliver the highest quality products to your customers.

In addition to Boster Bio Validation Protocols, you can also order from the Boster Biological Technology online store. Products are available online and through the company’s distribution network. These products can only be used for diagnostic and research purposes. Boster Biology Technology does not recommend them for human research. Therefore, you should always check your research with a trusted lab. Boster Biological Technology documentation is not intended to infringe patents.

Applications

The MATN2 gene has multiple applications and is a candidate biomarker for pilocytic astrocytoma. The gene is part of the genetic switch that drives all-or-nothing differentiation. This gene allows physicians to more accurately distinguish between clinically aggressive and indolent subtypes. Here, we review applications of the MATN2 gene and discuss its implications for cancer research.

Matn2 is expressed by a variety of committed proliferating cells and may have a general function during the early stages of cell differentiation and regeneration. It modulates cell-cell communication and the assembly of extracellular matrix elements. Further research will be required to understand how Matn2 functions. Unraveling its molecular mechanism will help researchers develop novel therapeutic strategies that will facilitate tissue repair and cancer diagnosis.

Numerous studies have shown Matn2 is important in muscle regeneration. The changes in weight of rat soleus muscles after regeneration is well-established. They reflect the progress of inflammatory and necrosis processes as well as repair. Northern analysis revealed that Matn2 expression rose up to four days after soleus regeneration by notexin. It declined after 4 days, and was partially overexpressed with the MyoD/Myog myogenic differentiation indicators. Furthermore, the transient accumulation Matn2 mRNA was not as rapid as the induction times of other ECM components.

Matn2 expression has been shown in peripheral nerves to stimulate the axonal expansion of DRG neuron. It is also associated with SC migration and adhesion. Matn2 expression is very low in adults but increases significantly during peripheral nerve reconstruction. Matn2-deficient mice show impaired SC migration and axonal proliferation. These functions can be restored by exogenous Matn2 in Matn2-deficient animals.

The MATN2 gene has also been implicated in idiopathic Scoliosis, mandibular prognathism and other conditions. It has been shown to be involved in tumor growth. It will be vital to develop a therapy for this condition if MATN2 is found to function. The gene is also essential to myoblast differentiation.

Research has also shown Matn2 may regulate myoblast differentiatelty. The transcription factors Nfi and MyoD regulate Matn2 expression. Both Nfi and Nfia are implicated in adult stem cell control, tissue regeneration, and TGF-b signaling. Nfix is well-known to regulate transcriptional switch from embryonic and fetal myogenesis. Nfia could be involved in the differentiation adult stem cells.