Megakaryocyte-associated tyrosine-protein kinase (MATK)

Could play a substantial role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site.

It can play an inhibitory role in the control of T-cell proliferation. .