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- Table of Contents
Facts about Megakaryocyte-associated tyrosine-protein kinase.
It can play an inhibitory role in the control of T-cell proliferation. .
Human | |
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Gene Name: | MATK |
Uniprot: | P42679 |
Entrez: | 4145 |
Belongs to: |
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protein kinase superfamily |
CHK; Csk-type protein tyrosine kinase; CTKEC 2.7.10.2; DKFZp434N1212; EC 2.7.10; Hematopoietic consensus tyrosine-lacking kinase; HHYLTK; hydroxyaryl-protein kinase; HYL tyrosine kinase; HYLCsk-homologous kinase; HYLTK; leukocyte carboxyl-terminal src kinase related; Lsk; megakaryocyte-associated tyrosine kinase; megakaryocyte-associated tyrosine-protein kinase; MGC1708; MGC2101; Protein kinase HYL; tyrosine kinase MATK; Tyrosine-protein kinase CTK; tyrosylprotein kinase
Mass (kDA):
56.469 kDA
Human | |
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Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (3777973..3801799, complement) |
Expressed in various myeloid cell lines, detected in brain and lung.
Cytoplasm. Membrane. In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
PMID: 8134117 by Sakano S., et al. Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase).
PMID: 8288563 by Bennett B.D., et al. Identification and characterization of a novel tyrosine kinase from megakaryocytes.