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MASP1 Antibodies
AND MASP1 ELISA kits, MASP1 Proteins
Many biological assays use antibodies to detect MASP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MASP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MASP1 antibodies...
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MASP1 Overview
Facts about Mannan-binding lectin serine protease 1.
Mannan-binding lectin serine protease 1 (MASP1)
Functions at the lectin pathway of complement, which plays an integral role in innate immunity by recognizing pathogens through patterns of glucose moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which contributes to activation of the related proteases MASP1 and MASP2.
Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the vital component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5.
Gene Information
| Human | |
|---|---|
| Gene Name: | MASP1 |
| Uniprot: | P48740 |
| Entrez: | 5648 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
Complement Factor MASP3; Complement factor MASP-3; Complement-activating component of Ra-reactive factor; CRARF1; CRARFMAP1; DKFZp686I01199; EC 3.4.21; EC 3.4.21.-; EC 3.4.21.104; EC 3.4.21.42; FLJ26383; mannan-binding lectin serine peptidase 1 (C4/C2 activating component ofRa-reactive factor); mannan-binding lectin serine protease 1 (C4/C2 activating component ofRa-reactive factor); mannan-binding lectin serine protease 1; Mannose-binding lectin-associated serine protease 1; Mannose-binding protein-associated serine protease; MAp44; MASP; MASP1; MASP-1; MASP3; MGC126283; MGC126284; PRSS5; Ra-
Molecular Weight
Mass (kDA):
79.247 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q27.3 |
| Sequence: | 3; NC_000003.12 (187216085..187293529, complement) |
Tissue Specificity
Protein of the plasma which is primarily expressed by liver.
Subcellular Localizations
Secreted.
Diseases
- Vertigo
- Inflammation
- Craniofacial Abnormalities
- Infective Disorder
- Congenital Anomaly Of Face
- Craniosynostosis
- Autoimmune Reaction
- Acute-phase Reaction
- Malignant Neoplasms
- Hepatitis
- Arthritis
- Liver Cirrhosis
Interacting Proteins
- MBL2
Pathways
- Complement Activation
- Coagulation
- Localization
- Pathogenesis
- Aging
- Opsonization
- Secretion
- Secretory Pathway
- Blood Coagulation
- Cell Migration
- Neural Crest Cell Migration
- Proteolysis
- Immune Response
PTMs
- Cleavage
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MASP1
bosterbio.com/bosterbio-gene-info-cards/MASP1
References
PMID: 8240317 by Takada F., et al. A new member of the C1s family of complement proteins found in a bactericidal factor, Ra-reactive factor, in human serum.
PMID: 8018603 by Sato T., et al. Molecular characterization of a novel serine protease involved in activation of the complement system by mannose-binding protein.