Reelin (RELN)

Extracellular matrix serine protease that plays a part in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration.

Affects migration of sympathetic preganglionic neurons in the spinal cord, where it appears to act as a barrier to neuronal migration. Enzymatic activity is essential for the modulation of cell adhesion.