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- Table of Contents
Facts about Reelin.
Affects migration of sympathetic preganglionic neurons in the spinal cord, where it appears to act as a barrier to neuronal migration. Enzymatic activity is essential for the modulation of cell adhesion.
Human | |
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Gene Name: | RELN |
Uniprot: | P78509 |
Entrez: | 5649 |
Belongs to: |
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reelin family |
EC 3.4.21; EC 3.4.21.-; Reeler; Reelin; RELN; RL; RLPRO1598
Mass (kDA):
388.388 kDA
Human | |
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Location: | 7q22.1 |
Sequence: | 7; NC_000007.14 (103471784..103989658, complement) |
Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% in patients with schizophrenia. Also expressed in fetal and adult liver.
Secreted, extracellular space, extracellular matrix.
PMID: 9049633 by DeSilva U., et al. The human reelin gene: isolation, sequencing, and mapping on chromosome 7.
PMID: 10328932 by Lambert de Rouvroit C., et al. Evolutionarily conserved, alternative splicing of reelin during brain development.