MARK1 Antibodies

AND MARK1 ELISA kits, MARK1 Proteins

Many biological assays use antibodies to detect MARK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MARK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MARK1 antibodies...

We validate the specificity of these antibodies to MARK1 by testing them on tissues known to express MARK1 positively and negatively. Browse below to find the MARK1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MARK1 Infographic by Boster Bio

All MARK1 Products

Product

Figures

Specificity

Applications

Price

Anti-MARK MARK1 Antibody

13 Q&As

Human, Mouse, Rat

$360
Cat # A04564-1
100 µl

Anti-MARK1/2/3/4 (N211) Antibody

Human, Mouse, Rat

IF, IHC

$405
Cat # A04564
100ul

Anti-Phospho-MARK1/2/3/4 (T215) Antibody

Human, Mouse, Rat

ELISA, IHC

$380
Cat # A04564T215
100ul

MARK1 Overview

Facts about Serine/threonine-protein kinase MARK1.

MARK1 3D structure. Source: alphafold

Serine/threonine-protein kinase MARK1 (MARK1)

Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation.

Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule- associated protein MAPT/TAU (PubMed:23666762).

Gene Information

Human
Gene Name:	MARK1
Uniprot:	Q9P0L2
Entrez:	4139

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.1; KIAA1477serine/threonine-protein kinase MARK1; MAP/microtubule affinity-regulating kinase 1MGC126512; MARKMGC126513

Molecular Weight

Mass (kDA):
89.003 kDA

Genomic Context


Human

Location:	1q41
Sequence:	1; NC_000001.11 (220528136..220664461)

Tissue Specificity

Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney.

Subcellular Localizations

Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cytoplasm. Cell projection, dendrite. Appears to localize to an intracellular network.

Diseases

Alzheimer's Disease
Malignant Neoplasms
Carcinogenesis
Tauopathies
Neurodegenerative Disorders
Tissue Adhesions
Dementia
Neoplasms
Cell Transformation, Neoplastic
Autistic Disorder
Stomach Neoplasms
Carcinoma

Paired Helical Filament
Neurofibrillary Tangles
Psychotic Disorders
Mental Disorders
Neuroblastoma
Malignant Neoplasm Of Stomach
Neoplasm Metastasis

Pathways

Hyperphosphorylation
Transport
Cell Death
Cell Division
Localization
Protein Phosphorylation
Cell Adhesion
Cell Cycle
Mitosis
Energy Homeostasis
Cell Migration
Fertilization
Cytokinesis

Asymmetric Cell Division
Translation
Cognition
Interphase
Intracellular Transport
Establishment Of Cell Polarity
Metaphase

PTMs

Phosphorylation
Deacetylation

Acetylation
Methylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MARK1

References

PMID: 14976552 by Lizcano J.M., et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

PMID: 9108484 by Drewes G., et al. MARK - a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.