MAPKAPK5 Antibodies

AND MAPKAPK5 ELISA kits, MAPKAPK5 Proteins

Many biological assays use antibodies to detect MAPKAPK5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAPKAPK5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAPKAPK5 antibodies...

We validate the specificity of these antibodies to MAPKAPK5 by testing them on tissues known to express MAPKAPK5 positively and negatively. Browse below to find the MAPKAPK5 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAPKAPK5 Infographic by Boster Bio

All MAPKAPK5 Products

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Product

Figures

Specificity

Applications

Price

MAPKAPK5 Colorimetric Cell-Based ELISA Kit

Human, Mouse

ELISA

$480
Cat # EKC1350
1 kit, containing one 96-well plate and all necessary reagents

MAPKAPK5 (Phospho-Thr182) Colorimetric Cell-Based ELISA Kit

Human, Mouse

ELISA

$540
Cat # EKC2617
1 kit, containing two 96-well plates and all necessary reagents

Anti-Phospho-PRAK (T182) MAPKAPK5 Antibody

Human, Mouse

ELISA, IHC, WB

$380
Cat # A07923T182
100ul

Anti-PRAK MAPKAPK5 Monoclonal Antibody

Human

ELISA, IHC, WB

$380
Cat # M07923
100ul

MAPKAPK5 Overview

Facts about MAP kinase-activated protein kinase 5.

MAPKAPK5 3D structure. Source: alphafold

MAP kinase-activated protein kinase 5 (MAPKAPK5)

Tumor suppressor serine/threonine-protein kinase involved with mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB.

Acts as a tumor suppressor by mediating Ras- induced senescence and phosphorylating p53/TP53. Involved in post- transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, two post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation.

Gene Information

Human
Gene Name:	MAPKAPK5
Uniprot:	Q8IW41
Entrez:	8550

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAPK-5; mitogen-activated protein kinase-activated protein kinase 5; p38-regulated/activated protein kinase; PRAKEC 2.7.11.1

Molecular Weight

Mass (kDA):
54.22 kDA

Genomic Context


Human

Location:	12q24.12-q24.13
Sequence:	12; NC_000012.12 (111842228..111902222)

Tissue Specificity

Expressed ubiquitously.

Subcellular Localizations

Cytoplasm. Nucleus. Translocates to the cytoplasm following phosphorylation and activation. Interaction with ERK3/MAPK6 or ERK4/MAPK4 and phosphorylation at Thr-182, activates the protein kinase activity, followed by translocation to the cytoplasm. Phosphorylation by PKA/PRKACA at Ser-115 also induces nuclear export.