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MAPK8IP3 Antibodies
AND MAPK8IP3 ELISA kits, MAPK8IP3 Proteins
Many biological assays use antibodies to detect MAPK8IP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAPK8IP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAPK8IP3 antibodies...
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MAPK8IP3 Overview
Facts about C-Jun-amino-terminal kinase-interacting protein 3.
C-Jun-amino-terminal kinase-interacting protein 3 (MAPK8IP3)
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of vesicle transport, through connections with the JNK-signaling parts and motor proteins (By similarity).
Promotes neuronal axon elongation in a kinesin- and JNK-dependent method. Activates cofilin in axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation.
Gene Information
| Human | |
|---|---|
| Gene Name: | MAPK8IP3 |
| Uniprot: | Q9UPT6 |
| Entrez: | 23162 |
Family
| Belongs to: |
|---|
| JIP scaffold family |
Alternative Names
c-Jun N-terminal kinase 1; EC 2.7.11; EC 2.7.11.24; JNK; JNK1 alpha protein kinase; JNK1 beta protein kinase; JNK1JNK1A2; JNK-46; JUN N-terminal kinase; MAP kinase 8; MAPK 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8; PRKM8JNK; protein kinase JNK1; SAPK1JNK21B1/2; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1
Molecular Weight
Mass (kDA):
147.457 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16p13.3 |
| Sequence: | 16; NC_000016.10 (1706183..1770351) |
Subcellular Localizations
Cytoplasm. Golgi apparatus. Cytoplasmic vesicle. Cell projection, growth cone. Cell projection, axon. Cell projection, dendrite. Cytoplasm, perinuclear region. Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells. KIF5A/B/C-mediated transportation to axon tips is essential for its function in enhancing neuronal axon elongation.
Diseases
- Malignant Neoplasms
- Neoplasms
- Diabetes Mellitus
- Inflammation
- Obesity
- Insulin Resistance
- Diabetes Mellitus, Non-insulin-dependent
- Carcinogenesis
- Pituitary Diseases
- Reperfusion Injury
- Malignant Neoplasm Of Pancreas
- Colorectal Cancer
Interacting Proteins
- LDLRAP1
Pathways
- Immune Response
- Pathogenesis
- Cell Cycle
- Localization
- Spermatogenesis
- Cell Proliferation
- Cell Death
- Cell Migration
- Cell Differentiation
- Stem Cell Differentiation
- Cell Cycle Arrest
- Reverse Transcription
- Methylation
PTMs
- Phosphorylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAPK8IP3
bosterbio.com/bosterbio-gene-info-cards/MAPK8IP3
References
PMID: 11214971 by Hattori A., et al. Characterization of long cDNA clones from human adult spleen.
PMID: 12189133 by Matsuura H., et al. Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1- JNK signaling pathway. A new mode of regulation of the MAP kinase cascade.