MAPK6 Antibodies

Mitogen-activated protein kinase 6 (MAPK6)

Atypical MAPK protein.

Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5.

The precise role of the complex formed with MAPKAPK5 is still unclear, but the complicated follows a complicated set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).

Gene Information

Human
Gene Name:	MAPK6
Uniprot:	Q16659
Entrez:	5597

Family

Belongs to:
protein kinase superfamily

Alternative Names

DKFZp686F03189; EC 2.7.11; EC 2.7.11.24; ERK3; ERK-3; ERK3p97-MAPK; Extracellular signal-regulated kinase 3; extracellular signal-regulated kinase, p97; HsT17250; MAP kinase 6; MAP kinase isoform p97; MAPK 6; MAPK6; mitogen-activated protein kinase 6; p97MAPK; PRKM6; protein kinase, mitogen-activated 5; protein kinase, mitogen-activated 6

Molecular Weight

Mass (kDA):
82.681 kDA

Genomic Context

Human
Location:	15q21.2
Sequence:	15; NC_000015.10 (52019219..52067375)

Tissue Specificity

Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.

Subcellular Localizations

Cytoplasm. Nucleus. Translocates to the cytoplasm following interaction with MAPKAPK5.

Diseases

• Malignant Neoplasms
• Neoplasms
• Tissue Adhesions
• Adenoma
• Testicular Hypogonadism
• Peripheral Nerve Injuries
• Melanoma
• Malignant Neoplasm Of Breast
• Inflammatory Bowel Diseases
• Stinging Sensation
• Hepatitis B
• Neoplasm Invasiveness
• Sarcoma

• Intestinal Diseases
• Fetal Growth Retardation
• Carcinoma
• Ulcer
• Dysplasia
• Atelectasis
• Tumor Angiogenesis

Interacting Proteins

• EGLN3
• MAPKAPK5

Pathways

• Cell Cycle
• Cell Proliferation
• Localization
• Cell Adhesion
• Translation
• Mitosis
• Pathogenesis
• Cell Migration
• Gluconeogenesis
• Superoxide Anion Generation
• Cell Cycle Arrest
• Inflammatory Response
• Cytoskeleton Organization

• Telomere Maintenance
• Seed Germination
• Spindle Assembly Checkpoint
• Wound Healing
• Meiosis
• Myoblast Differentiation
• Spindle Assembly

PTMs

• Phosphorylation
• Reduction

• Oxidation
• Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAPK6

Boster Bio: Best Uses Of The MaPK6 Marker

In this Boster Bio: Best Uses Of The MaPK6 Marker article You'll learn more about Steven Boster and the MAPK6 marker. You can look up his biographical information and learn more about his high-affinity primary antibodies. Learn how to submit your results for specific species, samples or applications. Boster's Product credits are also available, which can be applied for regardless of the location you conduct your research.

Benefits of Using The MAPK6 Marker

The study of A. Thalian which is an asexual plant found that MAPK6 expression increased after the plant was infected by a pathogen. MAPK-6 expression grew during the initial stages, but decreased in the middle and peaked at the final stage. However, the levels of expression during the control phase were low. Using the MAPK6 marker is an additional method to determine which plant cells express MAPK.

To determine the expression pattern of MAPK-6, we first conducted an analysis of the A. Thaliana plant in healthy and diseases. The Bradford method was employed to determine the amount of protein in the leaves. Protein concentrations in the different leaf samples are shown in Table 5. To determine the level of protein expression that differs at different stages of infection, we used SDS-PAGE (12.5 percent). In this way, we could determine the plants that are most susceptible to disease, and which are more susceptible.

We next tested the MAPK6 expression in infected leaves. The RNA was labelled with the MAPK-4 and MAPK-6 genes. We used the actin gene as an internal reference and an primer set of MAPK4 and MAPK6 partial gene products. The expected amplicons for the two MAP kinases were 243 and 161 bp, respectively. These results highlight the importance of the MAPK6 marker to determine abiotic stress tolerance.

Steven Boster's history

This short biography of Steven Boster will give an overview of his life and accomplishments. Boster began developing his first product in 1993. He went on to develop several products in the field of immunohistochemistry, including hundreds of primary antibodies. In the late 1990s, his company was one of China's largest antibody catalogs. PicoKine(tm), his company's proprietary ELISA platform, has been developed to offer high-sensitivity ELISA kit kits.

Steve Boster was born Joliet, IL. He worked in the retail industry for many years. He was also a member of Concordia Hall in Staunton, VA. Steve was survived by his wife, Frances, two daughters who are Crystal Boster and Natosha Peck - 6 Grandchildren and 4 brothers - Jack Boster and Sandra Blanton. He is also the proud uncle of two nephews and nieces.

High-affinity primary antibodies are offered by Boster

Boster's high affinity primary antibodies are suitable for flow cytometry. This is a highly sophisticated research technique that analyzes particles and cells to identify proteins. Boster's polyclonal and monoclonal antibodies have been extensively tested against a range of 250 human tissues as well as untransfected cell lines. This results in high affinity and sensitivity. Furthermore, Boster's antibodies are available in both pre-configured and custom-made formats, making it easy to modify any of their kits.

The High-affinity antibody of the company are designed for ELISA. Because they are highly specific, they are also able to eliminate non-specifically bound material. Boster's high affinity antibodies are essential for many research projects that make use of the use of antibodies. Here's an overview of some of the different types of primary antibodies available from Boster Bio:

Primary antibodies are immunoglobulins that specifically bind to an antigen of interest. They are distinguished by their affinity or specificity, which determines the extent of binding to the antigen. The more specific the antibody is, the better, since it is less likely to be able to bind to non-targeted antigens. High-affinity primary antibodies can identify purify, measure, and identify antigens in a range of samples.

Boster Bio also provides high-affinity primary antibodies made of rabbit polyclonal antibody. The company also offers monoclonal and polyclonal human antibody. Its product range includes products that treat neurodegenerative, autoimmune diseases and cardiac markers. The company also offers a wide range of diagnostic reagents to detect infectious diseases. The focus of the company is immunoassays, which are an excellent method to detect the presence or absence of an infection.

The monoclonal antibody available from Boster Bio are highly specific and high-affinity for the specific epitope of the antigen. They have minimal lot-to-lot variation and show minimal cross-reactivity not specific to the epitope. These antibodies are extremely specific and suitable for research and clinical applications. They're also great to use in ELIS-based assays which are used to identify specific proteins.

Besides the polyclonal antibodies offered by Boster Bio, high-affinity primary antibodies can also be produced by other companies, including Diatec and Absea. Both companies develop antibodies for rabbits and chickens. They also produce monoclonal antibodies which they create in rabbits, chickens and sheep. They also provide contract services. They can usually provide the antibodies that your laboratory needs.

The high-affinity antibodies provided by Boster Bio are M01, OTI2A2 MOAB-2 and OTI2A2. These antibodies have been purified and are available at a high-affinity price. Boster Bio's primary antibodies are high quality. All of their products are guaranteed to work. The company offers superior customer service and reasonable prices. You can make your purchase now!