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- Table of Contents
7 Citations
10 Citations 16 Q&As
6 Citations 16 Q&As
10 Citations 6 Q&As
6 Citations 16 Q&As
7 Citations 15 Q&As
Facts about Mitogen-activated protein kinase 3.
They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.
Human | |
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Gene Name: | MAPK3 |
Uniprot: | P27361 |
Entrez: | 5595 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.11; ERK1; ERK-1; ERK1p44-MAPK; ERT2; Extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; HS44KDAP; HUMKER1A; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase isoform p44; MAPK 1; MAPK 3; MAPK3; MGC20180; Microtubule-associated protein 2 kinase; Mitogen-activated protein kinase 1; mitogen-activated protein kinase 3; P44ERK1; p44-ERK1; p44mapk; PRKM3; PRKM3EC 2.7.11.24
Mass (kDA):
43.136 kDA
Human | |
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Location: | 16p11.2 |
Sequence: | 16; NC_000016.10 (30114105..30123309, complement) |
Cytoplasm. Nucleus. Membrane, caveola. Autophosphorylation at Thr-207 promotes nuclear localization.
PMID: 7687743 by Charest D.L., et al. Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1.
PMID: 1540184 by Owaki H., et al. Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs.
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