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MAPK13 Antibodies
AND MAPK13 ELISA kits, MAPK13 Proteins
Many biological assays use antibodies to detect MAPK13, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAPK13 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAPK13 antibodies...
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MAPK13 Infographic by Boster Bio
All MAPK13 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9721
100 μg/vial
Cat # PB9721
100 μg/vial
Dog, Human, Monkey, Mouse, Rat
IF, IHC, WB
$523
Cat # M03594
100 µl
Cat # M03594
100 µl
MAPK13 Overview
Facts about Mitogen-activated protein kinase 13.
Mitogen-activated protein kinase 13 (MAPK13)
Serine/threonine kinase which functions as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular reactions evoked by extracellular stimuli such as proinflammatory cytokines or physical strain resulting in direct activation of transcription factors such as ELK1 and ATF2.
Accordingly, p38 MAPKs phosphorylate a wide assortment of proteins and it has been estimated that they might have roughly 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms.
Gene Information
| Human | |
|---|---|
| Gene Name: | MAPK13 |
| Uniprot: | O15264 |
| Entrez: | 5603 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.24; MAP kinase 13; MAPK 13; MAPK13; MGC99536; mitogen-activated protein kinase 13; Mitogen-activated protein kinase p38 delta; p38 delta; p38delta; PRKM13; SAPK4MAP kinase p38 delta; Stress-activated protein kinase 4
Molecular Weight
Mass (kDA):
42.09 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.31 |
| Sequence: | 6; NC_000006.12 (36130513..36144521) |
Tissue Specificity
Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Malignant Pleural Mesothelioma
- Pleural Mesothelioma
- Mammary Neoplasms
- Mesothelioma
- Cell Invasion
- Cell Transformation, Neoplastic
- Cholangiocarcinoma
- Cystic Fibrosis
Interacting Proteins
- FPR1
- PRKD1
Pathways
- Methylation
- Dna Methylation
- Cell Cycle
- Pathogenesis
- Dna Hypermethylation
- Dna Hypomethylation
- Mitosis
- Immune Response
- Response To Vitamin
- Response To Paclitaxel
- Response To Vitamin D
- Viral Genome Replication
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAPK13
bosterbio.com/bosterbio-gene-info-cards/MAPK13
References
PMID: 9218798 by Goedert M., et al. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
PMID: 9374491 by Jiang Y., et al. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta.