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MAPK1 Antibodies
AND MAPK1 ELISA kits, MAPK1 Proteins
Many biological assays use antibodies to detect MAPK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAPK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAPK1 antibodies...
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MAPK1 Infographic by Boster Bio
All MAPK1 Products
Product
Figures
Specificity
Applications
Price
Anti-ERK2/MAPK1 Antibody Picoband®
5 Citations 7 Q&As
Human, Mouse, Rat
WB
$370
Cat # PA1310-1
100 μg/vial
Cat # PA1310-1
100 μg/vial
Anti-ERK2 Monoclonal Antibody
4 Citations
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M00030
100 μl
Cat # M00030
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1702
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1702
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$380
Cat # A00030Y222
100ul
Cat # A00030Y222
100ul
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, IP, IHC, WB
$523
Cat # M00030-1
100 µl
Cat # M00030-1
100 µl
MAPK1 Overview
Facts about Mitogen-activated protein kinase 1.
Mitogen-activated protein kinase 1 (MAPK1)
Serine/threonine kinase which acts as an important part of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 will be the 2 MAPKs which play an significant role in the MAPK/ERK cascade.
They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Based on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements.
Gene Information
| Human | |
|---|---|
| Gene Name: | MAPK1 |
| Uniprot: | P28482 |
| Entrez: | 5594 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.24; ERK; ERK2; ERK-2; ERK2MAP kinase isoform p42; ERT1; Extracellular signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAPK 1; MAPK1; MAPK2; mitogen-activated protein kinase 1; Mitogen-activated protein kinase 2; p38; p40; p41; p41mapk; p42mapk; p42-MAPK; PRKM1; PRKM1MAPK 2; PRKM2; protein tyrosine kinase ERK2
Molecular Weight
Mass (kDA):
41.39 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q11.22 |
| Sequence: | 22; NC_000022.11 (21759657..21867680, complement) |
Subcellular Localizations
Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Membrane, caveola. Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Inflammation
- Cell Invasion
- Tissue Adhesions
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Neoplasm Metastasis
- Tumor Angiogenesis
- Cell Transformation, Neoplastic
- Neoplasm Invasiveness
Interacting Proteins
- ARRB2
- BLVRA
- COPS6
- DUSP1
- Dusp2
- DUSP4
- DUSP5
- ETS1
- MAP2K1
- MAPK3
Pathways
- Cell Proliferation
- Cell Cycle
- Cell Death
- Cell Growth
- Secretion
- Pathogenesis
- Angiogenesis
- Cell Migration
- Localization
- Cell Adhesion
- Cell Differentiation
- Translation
- Transport
PTMs
- Phosphorylation
- Cleavage
- Dephosphorylation
- Ubiquitination
- Methylation
- Reduction
- Acetylation
Research Areas
- Angiogenesis
- Apoptosis
- Breast Cancer
- Cancer
- Diabetes Research
- Hypoxia
- Phospho-Specific
- Protein Kinase
- Signal Transduction
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAPK1
bosterbio.com/bosterbio-gene-info-cards/MAPK1
References
PMID: 1540184 by Owaki H., et al. Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs.
PMID: 1319925 by Gonzalez F.A., et al. Heterogeneous expression of four MAP kinase isoforms in human tissues.
5 Publications of Boster MAPK1 Antibodies & ELISA Kits
- PubMed ID: 26517513, Disulfiram inhibits TGF-?-induced epithelial-mesenchymal transition and stem-lik...
- PubMed ID: 28193911, eIF3i activity is critical for endothelial cells in tumor induced angiogenesis t...
- PubMed ID: 24718680, Ma Hr, Wang J, Chen Yf, Chen H, Wang Ws, Aisa Ha. Int J Mol Med. 2014 Jun;33(6):...
- PubMed ID: 21769431, Sang J, Chen Y, Tao Y. Mol Med Rep. 2011 Nov-Dec;4(6):1163-7. Doi: 10.3892/Mmr.2...
- PubMed ID: 26097571, Li Xl, Chen Xq, Zhang Mn, Chen N, Nie L, Xu M, Gong J, Shen Pf, Su Zz, Weng X, T...
*More publications can be found for each product on its corresponding product page