MAP4K2 Antibodies

AND MAP4K2 ELISA kits, MAP4K2 Proteins

Many biological assays use antibodies to detect MAP4K2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP4K2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP4K2 antibodies...

We validate the specificity of these antibodies to MAP4K2 by testing them on tissues known to express MAP4K2 positively and negatively. Browse below to find the MAP4K2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAP4K2 Infographic by Boster Bio

All MAP4K2 Products

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Product

Figures

Specificity

Applications

Price

Anti-M4K2 MAP4K2 Antibody

Human

ELISA, WB

$380
Cat # A09319
100ul

Anti-GCK/GLK MAP4K2 Antibody

Human, Rat

ELISA, WB

$380
Cat # A09319-1
100ul

Germinal Center Kinase (MAP4K2) (NM_004579) Human Over-expression Lysate

Human

$960
Cat # LS005871
100 µg

MAP4K2 Overview

Facts about Mitogen-activated protein kinase kinase kinase kinase 2.

MAP4K2 3D structure. Source: alphafold

Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2)

Serine/threonine-protein kinase which acts as an essential part of the MAP kinase signal transduction pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin.

To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8.

Gene Information

Human
Gene Name:	MAP4K2
Uniprot:	Q12851
Entrez:	5871

Family

Belongs to:

protein kinase superfamily

Alternative Names

B lymphocyte serine/threonine protein kinase; B lymphocyte serine/threonine-protein kinase; BL44; EC 2.7.11; EC 2.7.11.1; GC kinase; GCKMEK kinase kinase 2; Germinal center kinase; germinal centre kinase (GC kinase); MAPK/ERK kinase kinase kinase 2; mitogen-activated protein kinase kinase kinase kinase 2; Rab8 interacting protein; Rab8-interacting protein; RAB8IPMEKKK 2

Molecular Weight

Mass (kDA):
91.556 kDA

Genomic Context


Human

Location:	11q13.1
Sequence:	11; NC_000011.10 (64784918..64803248, complement)

Tissue Specificity

Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined.

Subcellular Localizations

Cytoplasm. Basolateral cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.

Diseases

Malignant Neoplasms
Endocrine Gland Neoplasms
Neoplasms
Multiple Endocrine Neoplasia Type 1
Malignant Tumor Of Colon
Colorectal Cancer
Genotoxic Stress
Multiple Endocrine Neoplasia

Sarcoma
Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)

Interacting Proteins

MAP3K1
POT1

Pathways

Dna Repair

PTMs

Phosphoprotein

Ubl conjugation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP4K2

References

PMID: 7515885 by Katz P., et al. Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center.

PMID: 7477268 by Pombo C.M., et al. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase.