MAP3K1 Antibodies

AND MAP3K1 ELISA kits, MAP3K1 Proteins

Many biological assays use antibodies to detect MAP3K1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAP3K1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAP3K1 antibodies...

We validate the specificity of these antibodies to MAP3K1 by testing them on tissues known to express MAP3K1 positively and negatively. Browse below to find the MAP3K1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAP3K1 Infographic by Boster Bio

All MAP3K1 Products

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Product

Figures

Specificity

Applications

Price

Anti-MEKK1/MAP3K1 Antibody Picoband®

1 Citations 1 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # PA1923
100 μg/vial

Anti-MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1) Monoclonal Antibody

5 Q&As

Human

IHC, WB

$486
Cat # M01972
100ug/vial

Anti-Phospho-MEK Kinase-1 (T1402) MAP3K1 Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A01972T1402
100ul

MAP3K1 Overview

Facts about Mitogen-activated protein kinase kinase kinase 1.

MAP3K1 3D structure. Source: alphafold

Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)

Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624).

May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the fundamental protein kinases of the NF- kappa-B pathway (PubMed:9808624).

Gene Information

Human
Gene Name:	MAP3K1
Uniprot:	Q13233
Entrez:	4214

Family

Belongs to:

protein kinase superfamily

Alternative Names

Map3k1; MAPK/ERK kinase kinase 1; MAPKKK1MAP/ERK kinase kinase 1; MEK kinase 1; MEKK1EC 2.7.11.25; MEKKMEKK 1; mitogen-activated protein kinase kinase kinase 1

Molecular Weight

Mass (kDA):
164.47 kDA

Genomic Context


Human

Location:	5q11.2
Sequence:	5; NC_000005.10 (56815543..56896152)

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Cell Transformation, Neoplastic
Carcinoma
Tissue Adhesions
Inflammation
Leukemia
Neoplasm Metastasis
Tumor Angiogenesis
Malignant Paraganglionic Neoplasm
Cell Invasion

Liver Carcinoma
Pertussis
Melanoma
Growth Arrest
Carcinogenesis
Malignant Squamous Cell Neoplasm
Pancreatic Neoplasm

Interacting Proteins

ARRB2
BRAF
DCAF7
FLNB
MAP2K4

MAP4K2
TRAF2

Pathways

Cell Death
Cell Proliferation
Cell Cycle
Cell Growth
Secretion
Induction Of Apoptosis
Angiogenesis
Localization
Cell Migration
Pathogenesis
Cell Differentiation
Cell Adhesion
Cell Cycle Arrest

Mapk Cascade
Chemotaxis
Cell Activation
Protein Phosphorylation
Immune Response
Proteolysis
T Cell Activation

PTMs

Phosphorylation
Cleavage
Ubiquitination
Dephosphorylation
Sumoylation

Acetylation
Nitrosylation
Phosphorothioation
Methylation
Myristoylation

Research Areas

Angiogenesis
Breast Cancer
Cancer
Lipid and Metabolism
MAP Kinase Signaling

mTOR Pathway
Protein Kinase
Signal Transduction
Tyrosine Kinases

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP3K1

References

PMID: 9808624 by Xia Y., et al. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension.

PMID: 8597633 by Vinik B.S., et al. Mapping of the MEK kinase gene (Mekk) to mouse chromosome 13 and human chromosome 5.

1 Publications of Boster MAP3K1 Antibodies & ELISA Kits

PubMed ID: -, MiRNA-let-7b decreases proliferation activities and development of follicular ce...

*More publications can be found for each product on its corresponding product page