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- Table of Contents
Facts about Microtubule-associated protein 1S.
Binds to DNA. Plays a role in apoptosis.
Human | |
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Gene Name: | MAP1S |
Uniprot: | Q66K74 |
Entrez: | 55201 |
Belongs to: |
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MAP1 family |
BPY2 interacting protein 1; BPY2IP1VCY2IP-1; C19orf5; chromosome 19 open reading frame 5; FLJ10669; MAP8MAP-1S; MGC133087; microtubule-associated protein 1S; Microtubule-associated protein 8; Variable charge Y chromosome 2-interacting protein 1; VCY2 interacting protein 1; VCY2-interacting protein 1; VCY2IP1BPY2-interacting protein 1
Mass (kDA):
112.211 kDA
Human | |
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Location: | 19p13.11 |
Sequence: | 19; NC_000019.10 (17719480..17734515) |
Expressed in neurons (at protein level). Expressed in spermatocytes, spermatids and spermatozoa. Expressed in the cerebral cortex. Highly expressed in testis. Moderately expressed in the brain, colon, heart, kidney, liver, lung, placenta, small intestine, spleen and stomach. Weakly expressed in muscle.
Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Detected in filopodia-like protrusions and synapses (By similarity). Detected in perinuclear punctate network corresponding to mitochondrial aggregates and in the nucleus in cells exhibiting apoptosis. Associated specifically with microtubules stabilized by paclitaxel and colocalizes with RASSF1 isoform A. In interphase cells, shows a diffuse cytoplasmic staining with partial localization to the microtubules. During the different stages of mitosis detected at the spindle microtubules.
PMID: 14627543 by Wong E.Y., et al. Identification and characterization of a VCY2 interacting protein-1; VCY2IP-1, a MAP-like protein.
PMID: 16297881 by Ding J., et al. Microtubule-associated protein 8 contains two microtubule binding sites.