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- Table of Contents
Facts about Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC.
Involved in the maturation of Asn-linked oligosaccharides.
Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a little bit of Man(5)GlcNAc..
Human | |
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Gene Name: | MAN1C1 |
Uniprot: | Q9NR34 |
Entrez: | 57134 |
Belongs to: |
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glycosyl hydrolase 47 family |
1,2-alpha-mannosidase IC; Alpha-1,2-mannosidase IC; EC 3.2.1.113; HMICProcessing alpha-1,2-mannosidase IC; MAN1A3; MAN1C; Mannosidase alpha class 1C member 1; mannosidase, alpha, class 1C, member 1; mannosyl-oligosaccharide 1,2-alpha-mannosidase IC; pp6318
Mass (kDA):
70.911 kDA
Human | |
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Location: | 1p36.11 |
Sequence: | 1; NC_000001.11 (25616820..25786207) |
Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta.
Golgi apparatus membrane; Single-pass type II membrane protein.
PMID: 10915796 by Tremblay L.O., et al. Characterization of a cDNA encoding a novel human Golgi alpha 1,2- mannosidase involved in N-glycan biosynthesis.