MAN1B1 Antibodies

AND MAN1B1 ELISA kits, MAN1B1 Proteins

Many biological assays use antibodies to detect MAN1B1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAN1B1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAN1B1 antibodies...

We validate the specificity of these antibodies to MAN1B1 by testing them on tissues known to express MAN1B1 positively and negatively. Browse below to find the MAN1B1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAN1B1 Infographic by Boster Bio

All MAN1B1 Products

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Product

Figures

Specificity

Applications

Price

Anti-MAN1B1/Ermani Antibody

5 Q&As

Human, Mouse

$360
Cat # A06537
100 µl

MAN1B1 (NM_016219) Human Over-expression Lysate

Human

$628
Cat # LS011253
100 µg

MAN1B1 Overview

Facts about Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase.

MAN1B1 3D structure. Source: alphafold

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase (MAN1B1)

Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims one alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it cuts the carbohydrates to Man(5-6)GlcNAc(2).

Gene Information

Human
Gene Name:	MAN1B1
Uniprot:	Q9UKM7
Entrez:	11253

Family

Belongs to:

glycosyl hydrolase 47 family

Alternative Names

alpha 1,2-mannosidase; EC 3.2.1.113; endoplasmic reticulum alpha-mannosidase 1; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1; endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; ER alpha 1,2-mannosidase; ER alpha-1,2-mannosidase; ER ManI; ER mannosidase 1; ERMan1; MAN1B1; Man9GlcNAc2-specific processing alpha-mannosidase; Man9GlcNAc2-specific-processing alpha-mannosidase; MANA-ER; Mannosidase alpha class 1B member 1; mannosidase, alpha, class 1B, member 1; MRT15; RP11-350O14.2

Molecular Weight

Mass (kDA):
79.58 kDA

Genomic Context


Human

Location:	9q34.3
Sequence:	9; NC_000009.12 (137086941..137109183)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Diseases

Liver Diseases

Pathways

Neuroprotection

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAN1B1

References

PMID: 10521544 by Tremblay L.O., et al. Cloning and expression of a specific human alpha1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis.

PMID: 10409699 by Gonzalez D.S., et al. Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis.