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- Table of Contents
, No Gclids
MAK Antibodies
AND MAK ELISA kits, MAK Proteins
Many biological assays use antibodies to detect MAK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAK antibodies...
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MAK Infographic by Boster Bio
All MAK Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1343
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1343
1 kit, containing one 96-well plate and all necessary reagents
MAK Overview
Facts about Serine/threonine-protein kinase MAK.
Serine/threonine-protein kinase MAK (MAK)
Critical for the regulation of ciliary length and required for the long term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner.
Plays a role in the transcriptional coactivation of AR. Could play an important role in spermatogenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | MAK |
| Uniprot: | P20794 |
| Entrez: | 4117 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
dJ417M14.2; EC 2.7.11; EC 2.7.11.22; male germ cell-associated kinaseserine/threonine protein kinase MAK; serine/threonine-protein kinase MAK
Molecular Weight
Mass (kDA):
70.581 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p24.2 |
| Sequence: | 6; NC_000006.12 (10762723..10838954, complement) |
Tissue Specificity
Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors.
Subcellular Localizations
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment. Photoreceptor inner segment. Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Nervousness
- Inhalation Exposure
- Inflammation
- Neoplasm Metastasis
- Prostatic Neoplasms
- Malignant Neoplasm Of Prostate
- Cholera
- Leukemia
- Neoplasm Recurrence, Local
Interacting Proteins
- AR
- FZR1
Pathways
- Pathogenesis
- Excretion
- Localization
- Spermatogenesis
- Mating
- Transport
- Meiosis
- Regeneration
- Sensitization
- Phagocytosis
- Cell Division
- Cell Proliferation
- Germination
PTMs
- Methylation
- Phosphorylation
- Acetylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAK
bosterbio.com/bosterbio-gene-info-cards/MAK
References
PMID: 12084720 by Xia L., et al. Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells.
PMID: 21835304 by Ozgul R.K., et al. Exome sequencing and cis-regulatory mapping identify mutations in MAK, a gene encoding a regulator of ciliary length, as a cause of retinitis pigmentosa.