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MAGEC2 Antibodies
AND MAGEC2 ELISA kits, MAGEC2 Proteins
Many biological assays use antibodies to detect MAGEC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAGEC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAGEC2 antibodies...
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MAGEC2 Infographic by Boster Bio
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MAGEC2 Overview
Facts about Melanoma-associated antigen C2.
Melanoma-associated antigen C2 (MAGEC2)
Proposed to boost ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation.
Proposed to behave through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. .
Gene Information
| Human | |
|---|---|
| Gene Name: | MAGEC2 |
| Uniprot: | Q9UBF1 |
| Entrez: | 51438 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Cancer/testis antigen 10; CT10MAGE-E1 antigen; HCA587MAGE-C2; hepatocellular cancer antigen 587; Hepatocellular carcinoma-associated antigen 587; MAGE-C2 antigen; MAGEE1MGC13377; melanoma antigen family C, 2; melanoma antigen, family E, 1, cancer/testis specific; melanoma-associated antigen C2
Molecular Weight
Mass (kDA):
41.163 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq27.2 |
| Sequence: | X; NC_000023.11 (142202342..142205290, complement) |
Tissue Specificity
Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non- small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression.
Subcellular Localizations
Cytoplasm. Nucleus. Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Melanoma
- Liver Carcinoma
- Liver Neoplasms
- Malignant Paraganglionic Neoplasm
- Neoplasm Metastasis
- Esophageal Neoplasms
- Malignant Neoplasm Of Lung
- Multiple Myeloma
- Cell Transformation, Neoplastic
- Malignant Squamous Cell Neoplasm
Interacting Proteins
- P4HA3
- SSX1
- SSX2
- TP53
- TRIM28
- UBE2H
Pathways
- Immune Response
- Methylation
- Cell Adhesion
- Reverse Transcription
- Cell Proliferation
- Secretion
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAGEC2
bosterbio.com/bosterbio-gene-info-cards/MAGEC2
References
PMID: 10699956 by Gure A.O., et al. CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational difference analysis.
PMID: 10861452 by Lucas S., et al. MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression.
1 Publications of Boster MAGEC2 Antibodies & ELISA Kits
- PubMed ID: 24687377, Yang F, Zhou X, Miao X, Zhang T, Hang X, Tie R, Liu N, Tian F, Wang F, Yuan J. B...
*More publications can be found for each product on its corresponding product page