MAGEA1 Antibodies

Melanoma-associated antigen 1 (MAGEA1)

May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation.

May play a role in embryonal development and tumor transformation or aspects of tumor development. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.

Gene Information

Human
Gene Name:	MAGEA1
Uniprot:	P43355
Entrez:	4100

Family

Belongs to:
No superfamily

Alternative Names

Antigen MZ2-E; Cancer/testis antigen 1.1; cancer/testis antigen family 1, member 1; CT1.1melanoma antigen family A 1; MAGE-1 antigen; MAGE1A; MAGE1melanoma antigen MAGE-1; melanoma antigen family A, 1 (directs expression of antigen MZ2-E); melanoma-associated antigen 1; melanoma-associated antigen MZ2-E; MGC9326

Molecular Weight

Mass (kDA):
34.342 kDA

Genomic Context

Human
Location:	Xq28
Sequence:	X; NC_000023.11 (153179284..153183880)

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

• Neoplasms
• Malignant Neoplasms
• Melanoma
• Carcinoma
• Neoplasm Metastasis
• Malignant Paraganglionic Neoplasm
• Liver Neoplasms
• Liver Carcinoma
• Lung Neoplasms
• Stomach Neoplasms
• Malignant Neoplasm Of Lung
• Malignant Neoplasm Of Stomach
• Malignant Squamous Cell Neoplasm

• Lymphatic Metastasis
• Skin Neoplasms
• Mammary Neoplasms
• Leukemia
• Malignant Neoplasm Of Breast
• Hepatitis
• Liver Cirrhosis

Interacting Proteins

• EID3
• HDAC1
• HYPK
• MIEF1
• RAB17

• RYDEN
• SFN
• SH3GLB2
• SNW1
• TRIM31

• ZNF564

Pathways

• Immune Response
• Reverse Transcription
• Methylation
• Demethylation
• Dna Methylation
• Cell Cycle
• Secretion
• Pathogenesis
• Spermatogenesis
• Cell Differentiation
• Localization
• Dna Demethylation
• Cell Proliferation

• Cytolysis
• Dedifferentiation
• Gene Silencing
• Dna Hypomethylation
• Hypersensitivity
• Cell Cycle Arrest
• Cytokine Production

PTMs

• Methylation
• Demethylation
• Biotinylation

• Deacetylation
• Acetylation
• Dephosphorylation

Research Areas

• Apoptosis
• Cancer
• Melanoma Cell Markers
• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAGEA1

Best Uses Of The MAGEA1 Marker By Boster Bio

Boster Bio Anti-MAGEA1 Monoclonal Antibody reacts positively with Human. It is stored at -20degC for one year and at 4degC for up to one month. Boster Bio antibodies are validated on positive and negative samples. They are also suitable in Immunofluorescence. For more information, continue reading. Boster Bio Anti–MAGEA1 MAGEA1 has been approved for use as an immunofluorescence antibody.

Anti-MAGE-1 Monoclonal Antibody

Boster Bio stocks a variety MAGE-1 antibodies for various uses. These products can be purchased in bulk quantities for a variety of purposes. The MAGE-1 Cell Based ELISA Kit, for example, is convenient and highly-efficient in monitoring the protein expression profile or cultured cells. It allows you to screen for activators and treatments in culture. This antibody may not be available in its original form. Consider purchasing the kit as part a multipack instead of buying each unit individually. Boster Rewards is available in these cases.

Patients with metastatic cancer or advanced melanoma could also be candidates. To be eligible for chemotherapy, they must have melanoma that has progressed or recurred. This treatment is also safe. The antibody is active at a high level and is available in clinical trials. It is also available for research purposes. However, it is important to consult your doctor and pharmacist before purchasing this product.

CIP-19's PBMCs, which were cultured for a period of one month, were tested for anti MAGE-3 TCR expression. The anti MAGE-A3 TCR activity was determined using a FITC labelled anti human CD8 antibody. These samples were analysed using a FACScanto II flow cell cytometer. The data obtained were analyzed with CellQuest or FlowJo software.

Analyzing human brain samples, Molecular analysis revealed that the antibody recognized several members the MAGE–A family. The TCR was able to recognize MAGE-A3, MAGE-9, MAGE-12.

This mAb could also be used to detect anti MAGE-1 expression in human cells. Ratanji et al. reported that the mAb stimulates IgG2a and IgG2b, which are related to the Th2 skew in the immune response. Despite these findings, mAb1 did not enhance IgM antibody levels in humans. These results are likely due in part to differences in the immunegenic potential of the mAb1 as well as the IgM repertoire.

This new antibody does not alter MAGE-1 expression but has a similar effect. It inhibits the growth and spread of tumor cells when MAGE-1 is present. It can even cause death of cells when combined with chemotherapy or other therapies. The effectiveness of these drugs depends on the patient. If the patient develops cancer, the treatment may not be stopped.

This product's catalog number is A14202. It has been tested against MAGE-1, MAGE-A3 and MAGE-A3 TCR gene engineered T cells. It reacted with human, mouse, and rat cells. It is therefore an excellent tool for research. It can also be used in different types of experiments. If you are planning to perform a molecular level antibody test, Anti-MAGE-1 Monoclonal Antibody from Boster Bio is an ideal choice.

Anti-MAGE - A1/A12 Marker

You might be interested to find out if Anti MAGE-A1/A12 from Boster Bio is compatible for your protein of choice when you're searching for an antibody. It reacts with Human MAGAC and can be tested in ELISA or WB assays. You can purchase a blocking protein for this antigen to determine if it will work with it. The cost of your immunogen will depend on its length.

The main causes of breast and esophageal tumors are mainly caused by Annexin A1. It could also be involved in metastatic processes. It is also found in cancer cells, and low levels may disrupt their biological behavior. Boster Bio makes a high-quality antibody compatible with this particular protein. For more information, please refer to the reference manual for Anti-MAGE-A1/A12 by Boster Bio.

MAGE A3/A12 is being targeted by the g-retroviral virus vector

To study the role and function of microRNAs in cucurbitatoxome development, a tobacco ringspot-based vector system has been developed. Gallaher, S.D. and Flutter, B. and Wallace, R. co-authored the work, along with female scientists Jain N. Loka, T. and Depani S.