MAG Antibodies

Myelin-associated glycoprotein (MAG)

Adhesion molecule which mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid- containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (By similarity). Not required for first myelination, but seems to play a role in the maintenance of normal axon myelination.

Protects motoneurons against apoptosis, also after trauma; protection against apoptosis is likely mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity).

Gene Information

Human
Gene Name:	MAG
Uniprot:	P20916
Entrez:	4099

Family

Belongs to:
immunoglobulin superfamily

Alternative Names

GMAsialic acid binding Ig-like lectin 4A; MAG; myelin associated glycoprotein; myelin-associated glycoprotein; sialic acid-binding immunoglobulin-like lectin 4A; Siglec4a; Siglec-4a; S-MAG

Molecular Weight

Mass (kDA):
69.069 kDA

Genomic Context

Human
Location:	19q13.12
Sequence:	19; NC_000019.10 (35292086..35313807)

Tissue Specificity

Both isoform 1 and isoform 2 are detected in myelinated structures in the central and peripheral nervous system, in periaxonal myelin and at Schmidt-Lanterman incisures (PubMed:9495552, PubMed:6200494). Detected in optic nerve, in oligodendroglia and in periaxonal myelin sheaths (PubMed:6200494). Detected in compact myelin (at protein level) (PubMed:6200494). Both isoform 1 and isoform 2 are detected in the central and peripheral nervous system (PubMed:9495552).

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Membrane raft.

Diseases

• Nervousness
• Tissue Adhesions
• Polyneuropathy
• Peripheral Neuropathy
• Paraproteinemias
• Demyelinating Diseases
• Demyelination
• Autoimmune Reaction
• Monoclonal Gammapathies
• Sclerosis
• Multiple Sclerosis
• Neoplasms

• Malignant Neoplasms
• Spinal Cord Injuries
• Monoclonal Gammopathy Of Undetermined Significance
• Autoimmune Diseases
• Demyelinating Polyneuropathy
• Nervous System Disorder

Pathways

• Regeneration
• Myelination
• Cell Adhesion
• Pathogenesis
• Axon Regeneration
• Localization
• Transport
• Glycosylation
• Secretion
• Oligodendrocyte Differentiation
• Immune Response
• Translation
• Cell Death

• Cell Differentiation
• Cell Cycle
• Brain Development
• Excretion
• Proteolysis
• Dna Repair
• Cell Proliferation

PTMs

• Phosphorylation
• Glycosylation
• Cleavage
• Deglycosylation
• Sulphation
• Dephosphorylation
• Acylation
• Oxidation
• Methylation

• Biotinylation
• Reduction
• Carboxylation
• Acetylation
• Demethylation
• Deamination
• Amidation
• Prenylation
• Ubiquitination

• Iodination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAG

Boster Bio MAG Marker - The Best Uses Of The MAG Marker

You may be wondering how to make the most of the MAG Marker in your workflow when you purchased it. You're in the right spot. In this article, we'll discuss the benefits of this new tool and the workflow it offers. After reading through this article, you'll be on your way to getting the most value from it. Here are a few examples:

Marker MAG

Developed for use in immunohistochemistry, the Boster Bio Anti-CD68 Macrophage Marker is tested on several species including Rat, Mouse, and Human. The Boster Bio Mag Marker is highly sensitive and precise in the detection of this marker. The guide contains thorough guidelines for preparing samples and troubleshooting tips. It also includes a step by step procedure to prepare samples for immunostaining.

IHC workflow

There are many ways to obtain tissue samples for immunohistochemistry. A biopsy or animal model is one common source. After an animal is dead for about two hours, autopsy samples can be obtained. Antigens can denature when they are left in the animal's body for more than 2 hours. They should be removed as soon as possible. Boster Bio offers detailed IHC sample preparation and immunostaining protocols that can ensure positive staining.

There are a variety of possible use scenarios for this marker, including the visualization of subcellular organelles in brain tissue. The MAG marker isn't particularly effective for epitopes with immunostaining that require antigen retrieval and/or reporter labeling. However it is useful in the IHC workflow, the use of the MAG marker makes it possible to visualize subcellular organelles in brain tissue that has been expanded.

IHC is a well-known option for the MAG marker. It can be used both for primary and secondary immunostaining. The MAG marker is highly specific for diverse types of tissues. It can be used in a variety of directions to determine the distribution cell components. It can be stored at 4°C for long-term storage. The Boster Bio MAG marker is available in several formats.

Since its introduction in 2006, the MAG marker has been utilized in immunohistochemistry. It is currently used in a variety of ways. For instance when it comes to cancer it is the MAG marker is used to differentiate between gliomas and osteoblasts. It is an excellent choice for IHC applications due to its high resolution, low background fluorescence, and less light scatter.

MAG Marker benefits

The advantages of the MAG marker go beyond marking cross-ties. A mag nail may also be used to mark important construction points and benchmarks. These monuments can be used to identify the future construction locations. A benchmark is an elevated vertical reference, usually made with a level or GPS system. In the majority of instances, benchmarks are established to aid in topographic surveys or construction. This means that the MAG marker can be a valuable instrument in both construction and surveying tasks.

The most significant benefit of the MAG Marker is that it is unable to move once it's been placed. This allows for more precise and less invasive procedures. Patients can enjoy better outcomes because they aren't required to undergo painful or invasive procedures in order to mark the lymph node that is cancerous. It is also commonly employed in surgical procedures for the removal of a cancer lump, like for an axillary lymph node removal.

Another benefit of the MAG Marker is that it can be used with a range of different rifle magazines. It can identify rifle magazines during training or on duty and also distinguish bullet grains from calibers. Another advantage is that the US Rigger Mag Markers are made from a tough silicone that will not change shape even under high temperatures. This means that they won't fall off the magazine. These advantages make the MAG Marker a great investment option for hunters and others engaged in the sport.

MAG Marker protocol

The MAG Marker protocol is used to mark suspicious breast tissue for biopsy. This procedure is performed in the operating room by using a magnetic probe to locate the Magseed. After the biopsy, the sample is sent to a pathologist for confirmation of tissue removal. Alternatively, needle localization, or wire localization can also be used to mark suspicious breast tissue for biopsy. The advantages of this method are obvious, and include simplicity. Disks are extremely easy to manipulate and can be placed to the right plane with ease.