Protein maelstrom homolog Antibodies

AND MAEL ELISA kits, Protein maelstrom homolog Proteins

Many biological assays use antibodies to detect Protein maelstrom homolog, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein maelstrom homolog in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein maelstrom homolog antibodies...

We validate the specificity of these antibodies to Protein maelstrom homolog by testing them on tissues known to express MAEL positively and negatively. Browse below to find the MAEL antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAEL Infographic by Boster Bio

All MAEL Products

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Anti-Maelstrom Antibody

Human, Mouse, Rat

ELISA, IF, ICC, WB

$449
Cat # A08829
0.1 mg

MAEL (NM_032858) Human Over-expression Lysate

Human

$628
Cat # LS084944
100 µg

Anti-MAEL Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A08829-1
100 µg/vial

MAEL Overview

Facts about Protein maelstrom homolog.

MAEL 3D structure. Source: alphafold

Protein maelstrom homolog (MAEL)

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts through the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons.

Its association with piP- bodies indicates a participation in the secondary piRNAs metabolic procedure. Required for the localization of germ-cell facets to the meiotic nuage (By similarity).

Gene Information

Human
Gene Name:	MAEL
Uniprot:	Q96JY0
Entrez:	84944

Family

Belongs to:

maelstrom family

Alternative Names

cancer/testis antigen 128; CT128; FLJ14904; maelstrom homolog (Drosophila); protein maelstrom homolog; RP11-102C16.1

Molecular Weight

Mass (kDA):
49.219 kDA

Genomic Context


Human

Location:	1q24.1
Sequence:	1; NC_000001.11 (166921121..167022214)

Tissue Specificity

Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter.

Subcellular Localizations

Cytoplasm. Nucleus. Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity).

Diseases

Malignant Neoplasms
Colorectal Neoplasms
Colorectal Cancer
Testicular Neoplasms
Male Infertility
Precocious Puberty
Gonorrhea
Genomic Instability
Angina Pectoris
Sterility
Infertility
Myocardial Infarction
Urethral Diseases

Neoplasms
Coronary Stenosis
Azoospermia
Cryptorchidism
Dental Plaque
Acute Coronary Syndrome
Inflammation

Pathways

Localization
Methylation
Dna Methylation
Spermatogenesis
Meiosis
Transport
Rna Processing
Oogenesis
Gene Silencing
Immune Response
Larval Development
Nuclear Transport
Oocyte Development

Axis Specification
Translation
Cell Death
Female Meiosis
Dna Damage Checkpoint
Sex Differentiation
Meiosis I

PTMs

Methylation

Demethylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAEL

References

PMID: 19693694 by Xiao L., et al. Identification of a novel human cancer/testis gene MAEL that is regulated by DNA methylation.