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- Table of Contents
Facts about Mitotic spindle assembly checkpoint protein MAD2A.
.
Human | |
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Gene Name: | MAD2L1 |
Uniprot: | Q13257 |
Entrez: | 4085 |
Belongs to: |
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MAD2 family |
HSMAD2; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2 mitotic arrest deficient-like 1 (yeast); MAD2L1; MAD2-like protein 1; MAD2mitotic arrest deficient, yeast, homolog-like 1; Mitotic arrest deficient 2-like protein 1; mitotic spindle assembly checkpoint protein MAD2A
Mass (kDA):
23.51 kDA
Human | |
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Location: | 4q27 |
Sequence: | 4; NC_000004.12 (120055623..120066848, complement) |
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Recruited by MAD1L1 to unattached kinetochores (Probable). Recruited to the nuclear pore complex by TPR during interphase. Recruited to kinetochores in late prometaphase after BUB1, CENPF, BUB1B and CENPE. Kinetochore association requires the presence of NEK2. Kinetochore association is repressed by UBD.
PMID: 8824189 by Li Y., et al. Identification of a human mitotic checkpoint gene: hsMAD2.
PMID: 11390010 by Gemma A., et al. Genomic structure of the human MAD2 gene and mutation analysis in human lung and breast cancers.