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- Table of Contents
Facts about Ly6/PLAUR domain-containing protein 3.
May be involved in tumor development. .
Human | |
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Gene Name: | LYPD3 |
Uniprot: | O95274 |
Entrez: | 27076 |
Belongs to: |
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No superfamily |
C4.4A; C4.4A2310061G07Rik; GPI-anchored metastasis-associated protein C4.4A homolog; GPI-anchored metastasis-associated protein homolog; LY6/PLAUR domain containing 3; ly6/PLAUR domain-containing protein 3; LYPD3; Matrigel-induced gene C4 protein; MIG-C4
Mass (kDA):
35.971 kDA
Human | |
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Location: | 19q13.31 |
Sequence: | 19; NC_000019.10 (43460787..43465608, complement) |
Expressed in placenta, skin and urothelium. Found in suprabasal keratinocytes of chronic wounds. Weak expression is found in esophagus and peripheral blood mononuclear cells. Found in the majority of primary and metastatic transitional cell carcinomas (TCCs) and as well in breast cancer tissues, but not in adjacent normal tissues. High expression is found in the tumor component of some noninvasive superficial lesions and in invasive and metastatic urothelial cancers.
Cell membrane; Lipid-anchor, GPI-anchor.
PMID: 11245483 by Smith B.A., et al. Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium.
PMID: 11179665 by Wuerfel J., et al. Cloning of the human homologue of the metastasis-associated rat C4.4A.