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Lyar Antibodies
AND Lyar ELISA kits, Lyar Proteins
Many biological assays use antibodies to detect Lyar, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Lyar in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Lyar antibodies...
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Lyar Overview
Facts about Cell growth-regulating nucleolar protein.
Cell growth-regulating nucleolar protein (Lyar)
Plays a role in the maintenance of the suitable processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to make 18S and 28S rRNAs (By similarity). Also acts at the level of transcription regulation.
Along with PRMT5, binds embryonic globin promoter (By similarity). In neuroblastoma cells, may also repress the expression of oxidative stress genes, such as CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41 (By similarity).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Lyar |
| Uniprot: | Q08288 |
| Entrez: | 17089 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
cell growth-regulating nucleolar protein; FLJ20425; Ly1 reactive homolog (mouse); LYAR; PNAS-5; ZLYAR
Molecular Weight
Mass (kDA):
43.736 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 5 B3|5 20.29 cM |
| Sequence: | 5; |
Tissue Specificity
Predominantly expressed in testis, in germ cells, and at a moderate level in spleen, liver and lung (at protein level) (PubMed:19489080, PubMed:23212345, PubMed:24990247). Very high levels in spermatogonia, spermatocytes and round spermatids, but not in testicular sperm and mature sperm (at protein level) (PubMed:20339383, PubMed:23212345, PubMed:24990247). Expressed in ovary (PubMed:20339383). Expressed in the retina, including in photoreceptor outer segments (at protein level) (PubMed:25735755). Expressed in undifferentiated embryonic stem cells (PubMed:19489080, PubMed:23212345).
Diseases
- Neoplasms
- Autoimmunity
- Leukemogenesis
- Exencephaly
- Neoplasms, Radiation-induced
- Leukemia, T-cell
- Uterine Neoplasms
- Autoimmune Diseases
- Malignant Neoplasm Of Lung
- Carcinoma
- Malignant Neoplasms
- Autoimmune Reaction
Pathways
- Cell Growth
- Cellular Response To Ionizing Radiation
- Response To Ionizing Radiation
- Programmed Cell Death
- Cell Death
- Pathogenesis
PTMs
Research Areas
- Cytokine Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Lyar
bosterbio.com/bosterbio-gene-info-cards/Lyar
References
PMID: 8491376 by Su L., et al. LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation.
PMID: 19489080 by Li H., et al. Ly-1 antibody reactive clone is an important nucleolar protein for control of self-renewal and differentiation in embryonic stem cells.