LZTS1 Antibodies

AND LZTS1 ELISA kits, LZTS1 Proteins

Many biological assays use antibodies to detect LZTS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LZTS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LZTS1 antibodies...

We validate the specificity of these antibodies to LZTS1 by testing them on tissues known to express LZTS1 positively and negatively. Browse below to find the LZTS1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LZTS1 Infographic by Boster Bio

All LZTS1 Products

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Product

Figures

Specificity

Applications

Price

Anti-LZTS1 Antibody (N-term)

Human, Mouse

$299
Cat # A06359
80 µl

Anti-LZTS1 Mouse Monoclonal Antibody [Clone ID: OTI3D12]

Human, Mouse, Rat

$523
Cat # M06359
100 µl

LZTS1 (NM_021020) Human Over-expression Lysate

Human

$628
Cat # LS011178
100 µg

LZTS1 Overview

Facts about Leucine zipper putative tumor suppressor 1.

LZTS1 3D structure. Source: alphafold

Leucine zipper putative tumor suppressor 1 (LZTS1)

Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation.

May act as a tumor suppressor. .

Gene Information

Human
Gene Name:	LZTS1
Uniprot:	Q9Y250
Entrez:	11178

Family

Belongs to:

LZTS family

Alternative Names

F37; F37/esophageal cancer-related gene-coding leucine-zipper motifFez1; FEZ1leucine zipper putative tumor suppressor 1; leucine zipper, putative tumor suppressor 1

Molecular Weight

Mass (kDA):
66.613 kDA

Genomic Context


Human

Location:	8p21.3
Sequence:	8; NC_000008.11 (20246165..20303963, complement)

Tissue Specificity

Highly expressed in testis, prostate, spleen, thymus, ovary and brain. Detected at lower levels in heart, placenta, small intestine, colon, liver, kidney, skeletal muscle and pancreas. Not detectable in primary tumors from breast and prostate and in many cancer cell lines.

Subcellular Localizations

Cytoplasm. Cell membrane. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity).

Diseases

Malignant Neoplasms
Neoplasms
Muscular Fasciculation
Carcinoma
Schizophrenia
Neoplasm Metastasis
Malignant Neoplasm Of Urinary Bladder
Prostatic Neoplasms
Malignant Neoplasm Of Breast
Bladder Neoplasm
Ovarian Neoplasm
Malignant Paraganglionic Neoplasm

Mental Disorders
Leukoencephalopathy, Progressive Multifocal
Leukoencephalopathies
Malignant Neoplasm Of Prostate
Mammary Neoplasms
Psychotic Disorders
Cell Transformation, Neoplastic

Interacting Proteins

CDC25C

Pathways

Mitosis
Cell Growth
Cell Cycle
Localization
Methylation
Transport
Anaphase
Dna Methylation
Metaphase
M Phase
Chromosome Segregation
Nuclear Transport
Regulation Of Mitosis

Prophase
Cell Proliferation
Regulation Of Cell Growth
Pathogenesis
Cell Adhesion
Dna Hypermethylation
Proteolysis

PTMs

Methylation
Phosphorylation

Dephosphorylation
Myristoylation

Research Areas

Cell Cycle and Replication
Prostate Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LZTS1

References

PMID: 10097140 by Ishii H., et al. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors.

PMID: 11464283 by Cabeza-Arvelaiz Y., et al. Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22.