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Lactotransferrin Antibodies
AND LTF ELISA kits, Lactotransferrin Proteins
Many biological assays use antibodies to detect Lactotransferrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Lactotransferrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Lactotransferrin antibodies...
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LTF Infographic by Boster Bio
All LTF Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, WB
$370
Cat # A00633-1
100 μg/vial
Cat # A00633-1
100 μg/vial
LTF Overview
Facts about Lactotransferrin.
Lactotransferrin (LTF)
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. .
Gene Information
| Human | |
|---|---|
| Gene Name: | LTF |
| Uniprot: | P02788 |
| Entrez: | 4057 |
Family
| Belongs to: |
|---|
| transferrin family |
Alternative Names
EC 3.4.21; EC 3.4.21.-; GIG12; growth-inhibiting protein 12; HEL110; HLF2; Kaliocin-1; Lactoferricin; Lactoferrin; Lactoferroxin; Lactotransferrin; LF; LTF; neutrophil lactoferrin; Talalactoferrin
Molecular Weight
Mass (kDA):
78.182 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.31 |
| Sequence: | 3; NC_000003.12 (46435645..46485234, complement) |
Tissue Specificity
High levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine. In kidney, detected in the distal collecting tubules in the medulla but not in the cortical region or in blood vessels. Detected in peripheral blood neutrophils (at protein level). Isoform 1 and isoform DeltaLf are expressed in breast, prostate, spleen, pancreas, kidney, small intestine, lung, skeletal muscle, uterus, thymus and fetal liver. Isoform 1 is expressed in brain, testis and peripheral blood leukocytes; isoform DeltaLf is barely detectable in these tissues. Isoform DeltaLf is expressed in placenta, liver and ovary; isoform 1 is barely detectable in these tissues. In kidney, isoform 1 is expressed at high levels in the collecting tubules of the medulla but at very low levels in the cortex.
Subcellular Localizations
[Isoform 1]: Secreted. Cytoplasmic granule. Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils.; [Isoform DeltaLf]: Cytoplasm. Nucleus. Mainly localized in the cytoplasm.
Diseases
- Hypoxia
- Anoxia
- Apnea
- Neoplasms
- Malignant Neoplasms
- Disease Of Adrenal Medulla
- Carcinoma
- Sleep Apnea Syndromes
- Nervousness
- Malaria, Falciparum
- Malaria
- Depressive Disorder
- Infective Disorder
Pathways
- Reflex
- Sensitization
- Long-term Memory
- Immune Response
- Pathogenesis
- Synaptic Transmission
- Localization
- Transport
- Lactation
- Secretion
- Translation
- Proteolysis
- Response To Hypoxia
PTMs
- Phosphorylation
- Methylation
- Glycosylation
- Demethylation
- Carboxylation
Research Areas
- Amino Acids, Drugs and other small molecules
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LTF
bosterbio.com/bosterbio-gene-info-cards/LTF
References
PMID: 2402455 by Rey M.W., et al. Complete nucleotide sequence of human mammary gland lactoferrin.
PMID: 9122171 by Siebert P.D., et al. Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines.