CD180 antigen Antibodies

AND CD180 ELISA kits, CD180 antigen Proteins

Many biological assays use antibodies to detect CD180 antigen, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CD180 antigen in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CD180 antigen antibodies...

We validate the specificity of these antibodies to CD180 antigen by testing them on tissues known to express CD180 positively and negatively. Browse below to find the CD180 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CD180 Infographic by Boster Bio

All CD180 Products

Product

Figures

Specificity

Applications

Price

Anti-CD180/Rp105 Antibody

5 Q&As

Human, Mouse, Rat

$399
Cat # A05085
100μl

Anti-RP105 CD180 Antibody

Human, Mouse

ELISA, IHC-P, WB

$449
Cat # A05085-1
0.1 mg

CD180 Overview

Facts about CD180 antigen.

CD180 3D structure. Source: alphafold

CD180 antigen (CD180)

May collaborate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation.

Also involved in the life/death decision of B-cells (By similarity). .

Gene Information

Human
Gene Name:	CD180
Uniprot:	Q99467
Entrez:	4064

Family

Belongs to:

Toll-like receptor family

Alternative Names

CD180 antigenMGC126233; CD180 molecule; CD180; Ly64; LY64MGC126234; Ly78; Lymphocyte antigen 64; lymphocyte antigen-64, radioprotective, 105kDa; Radioprotective 105 kDa protein; RP105; RP105lymphocyte antigen 64 (mouse) homolog, radioprotective, 105kD

Molecular Weight

Mass (kDA):
74.179 kDA

Genomic Context


Human

Location:	5q12.3
Sequence:	5; NC_000005.10 (67179613..67196799, complement)

Tissue Specificity

Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

Lupus Erythematosus, Systemic
Leukemia
Chronic Lymphocytic Leukemia
Infective Disorder
Autoimmune Diseases
Inflammation
Innate Immune Response
Autoimmune Reaction
Lymphoid Leukemia
Autoimmunity
Rheumatism
Neoplasms
Lymphoma

Bacterial Infections
Malignant Paraganglionic Neoplasm
Leucocytic Infiltrate
Leukemia, B-cell
Pneumonia
Virus Diseases
Aneurysm

Interacting Proteins

LY86

Pathways

Pathogenesis
Cell Activation
Secretion
Immune Response
B Cell Activation
Innate Immune Response
Cell Proliferation
B Cell Proliferation
Lymphocyte Activation
Cell Adhesion
Response To Lipopolysaccharide
Aging
Inflammatory Response

Chemotaxis
Lymphocyte Proliferation
Toll-like Receptor Signaling Pathway
Cell Development
Glycosylation
Endocytosis
Localization

PTMs

Phosphorylation

Research Areas

Adaptive Immunity
Immunology
Innate Immunity

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CD180

References

PMID: 8975706 by Miura Y., et al. Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64).

PMID: 9763566 by Miura Y., et al. RP105 is associated with MD-1 and transmits an activation signal in human B cells.