Leukotriene C4 synthase Antibodies

AND LTC4S ELISA kits, Leukotriene C4 synthase Proteins

Many biological assays use antibodies to detect Leukotriene C4 synthase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Leukotriene C4 synthase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Leukotriene C4 synthase antibodies...

We validate the specificity of these antibodies to Leukotriene C4 synthase by testing them on tissues known to express LTC4S positively and negatively. Browse below to find the LTC4S antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LTC4S Infographic by Boster Bio

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LTC4S (NM_145867) Human Over-expression Lysate

Human

$628
Cat # LS004056
100 µg

LTC4S Overview

Facts about Leukotriene C4 synthase.

LTC4S 3D structure. Source: alphafold

Leukotriene C4 synthase (LTC4S)

Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4. .

Gene Information

Human
Gene Name:	LTC4S
Uniprot:	Q16873
Entrez:	4056

Family

Belongs to:

MAPEG family

Alternative Names

EC 4.4.1.20; leukotriene C4 synthase; Leukotriene-C(4) synthase; LTC4 synthase; MGC33147

Molecular Weight

Mass (kDA):
16.567 kDA

Genomic Context


Human

Location:	5q35.3
Sequence:	5; NC_000005.10 (179793986..179796647)

Tissue Specificity

Detected in lung, platelets and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells and platelets.

Subcellular Localizations

Nucleus outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Asthma
Inflammation
Rhinorrhea
Respiration Disorders
Urticaria
Polyps
Bronchial Hyperreactivity
Anaphylaxis
Cerebrovascular Accident
Nasal Polyps
Dysequilibrium Syndrome

Sinusitis
Reperfusion Injury
Immediate Hypersensitivity
Allergic Rhinitis (disorder)
Hepatic Ischaemia
Fibrosis

Pathways

Pathogenesis
Conjugation
Hypersensitivity
Anaphylaxis
Localization
Secretion
Translation
Lipoxygenase Pathway
Transport
Osteoclast Differentiation
Cell Activation
Osteoblast Differentiation
Immune Response

Muscle Contraction
Mast Cell Activation
Inflammatory Response
Cell Maturation
Reverse Transcription
Response To Histamine
Prophase

PTMs

Phosphorylation

Glycosylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LTC4S

References

PMID: 8052639 by Lam B.K., et al. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4.

PMID: 7937884 by Welsch D.J., et al. Molecular cloning and expression of human leukotriene-C4 synthase.