Lrrk2 Antibodies

AND Lrrk2 ELISA kits, Lrrk2 Proteins

Many biological assays use antibodies to detect Lrrk2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Lrrk2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Lrrk2 antibodies...

We validate the specificity of these antibodies to Lrrk2 by testing them on tissues known to express Lrrk2 positively and negatively. Browse below to find the Lrrk2 antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Lrrk2 Infographic by Boster Bio

All Lrrk2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-LRRK2 Antibody Picoband®

15 Q&As

Human, Mouse, Rat

$370
Cat # PB9281
100 μg/vial

Anti-Phospho-LRRK2 (S935) Rabbit Monoclonal Antibody

15 Q&As

Human, Mouse

IF, ICC, WB

$370
Cat # P00221
100 μl

Anti-LRRK2 Rabbit Monoclonal Antibody

4 Q&As

Human, Mouse, Rat

IP, IF, IHC, ICC, WB

$370
Cat # M00221-2
100 μl

Anti-LRRK2 Rabbit Monoclonal Antibody

15 Q&As

Human, Mouse, Rat

IP, IF, IHC, ICC, WB

$370
Cat # M00221
100 μl

Anti-LRRK2 Rabbit Monoclonal Antibody

16 Q&As

Human, Mouse

IF, IHC, ICC, WB

$370
Cat # M00221-1
100 μl

Anti-LRRK2 Antibody (C-term)

Human

Flow Cytometry, IHC, WB

$299
Cat # M00221-3
80 µl

LRRK2 (NM_198578) Human Over-expression Lysate

Human

$960
Cat # LS120892
100 µg

Lrrk2 Overview

Facts about Leucine-rich repeat serine/threonine-protein kinase 2.

Leucine-rich repeat serine/threonine-protein kinase 2 (Lrrk2)

Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes.

Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent method. Regulates neuronal process morphology in the whole central nervous system (CNS).

Gene Information

Mouse
Gene Name:	Lrrk2
Uniprot:	Q5S006
Entrez:	66725

Family

Belongs to:

protein kinase superfamily

Alternative Names

augmented in rheumatoid arthritis 17; AURA17; Dardarin; DKFZp434H2111; EC 2.7.11.1; FLJ45829; leucine-rich repeat kinase 2; leucine-rich repeat serine/threonine-protein kinase 2; LRRK2; PARK8; PARK8DARDARIN; Parkinson disease (autosomal dominant) 8; RIPK7; ROCO2

Molecular Weight

Mass (kDA):
284.732 kDA

Genomic Context


Mouse

Location:	15\|15 E3
Sequence:	15;

Tissue Specificity

Expressed in the brain (at protein level). Detected throughout the adult brain. Expressed in deep cerebral cortex layers, superficial cingulate cortex layers, the piriform cortex, hippocampal formation, caudate putamen, substantia nigra, the basolateral and basomedial anterior amygdala nuclei, reticular thalamic nucleus and also in the cerebellar granular cell layer. Highly expressed in the striatum, cortex and olfactory tubercle. Little or no expression in the substantia nigra, where dopaminergic neurons preferentially degenerate in Parkinson disease. Expression is particularly high in brain dopaminoceptive areas. High and strikingly specific expression in striatum and parts of cortex and no signals in dopamine neurons.